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Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity

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Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity. / Asikainen, Sanja; Paakinaho, Kaarlo; Kyhkynen, Anna Kaisa; Hannula, Markus; Malin, Minna; Ahola, Niina; Kellomäki, Minna; Seppälä, Jukka.

In: European Polymer Journal, Vol. 113, 01.04.2019, p. 165-175.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Asikainen, S, Paakinaho, K, Kyhkynen, AK, Hannula, M, Malin, M, Ahola, N, Kellomäki, M & Seppälä, J 2019, 'Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity', European Polymer Journal, vol. 113, pp. 165-175. https://doi.org/10.1016/j.eurpolymj.2019.01.056

APA

Asikainen, S., Paakinaho, K., Kyhkynen, A. K., Hannula, M., Malin, M., Ahola, N., ... Seppälä, J. (2019). Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity. European Polymer Journal, 113, 165-175. https://doi.org/10.1016/j.eurpolymj.2019.01.056

Vancouver

Asikainen S, Paakinaho K, Kyhkynen AK, Hannula M, Malin M, Ahola N et al. Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity. European Polymer Journal. 2019 Apr 1;113:165-175. https://doi.org/10.1016/j.eurpolymj.2019.01.056

Author

Asikainen, Sanja ; Paakinaho, Kaarlo ; Kyhkynen, Anna Kaisa ; Hannula, Markus ; Malin, Minna ; Ahola, Niina ; Kellomäki, Minna ; Seppälä, Jukka. / Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity. In: European Polymer Journal. 2019 ; Vol. 113. pp. 165-175.

Bibtex - Download

@article{b8e0d9879d8a458ead1ad99258664806,
title = "Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity",
abstract = "The ability to release active agents from a porous scaffold structure in situ enables the simultaneous structural support for the cells proliferating and differentiating towards tissue as well as the stimulation of tissue regeneration. Due to the great potentiality of such approach, drug-releasing scaffolds were fabricated from hydrolytically degradable polymers. Three copolymers of poly(ethylene glycol), ɛ-caprolactone, L- and D,L-lactide were synthesized and blended with bone-growth inducing active agents, dexamethasone (DM) and 2-phospho-L-ascorbic acid trisodium salt (AS). Porous scaffolds were prepared by means of super-critical carbon dioxide foaming. In the final scaffold structures, the particle size, location and the water solubility of the drug affected the release kinetics. As the large and water soluble AS particles were more exposed to the buffer solution compared to small DM particles, the AS release was burst-like whereas DM showed a long-term release. The material structure had a significant effect on the release kinetics as the porous scaffolds released active agents faster compared to the solid cylinders. Furthermore, this study showed the strong effect of polymer degradation and wettability on the release, which were more determinative than the pore architecture.",
keywords = "2-Phospho-L-ascorbic acid trisodium salt, Bulk degradation, Dexamethasone, Drug release, Hydrolytic degradation, Supercritical carbon dioxide foaming",
author = "Sanja Asikainen and Kaarlo Paakinaho and Kyhkynen, {Anna Kaisa} and Markus Hannula and Minna Malin and Niina Ahola and Minna Kellom{\"a}ki and Jukka Sepp{\"a}l{\"a}",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.eurpolymj.2019.01.056",
language = "English",
volume = "113",
pages = "165--175",
journal = "European Polymer Jounal",
issn = "0014-3057",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Hydrolysis and drug release from poly(ethylene glycol)-modified lactone polymers with open porosity

AU - Asikainen, Sanja

AU - Paakinaho, Kaarlo

AU - Kyhkynen, Anna Kaisa

AU - Hannula, Markus

AU - Malin, Minna

AU - Ahola, Niina

AU - Kellomäki, Minna

AU - Seppälä, Jukka

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The ability to release active agents from a porous scaffold structure in situ enables the simultaneous structural support for the cells proliferating and differentiating towards tissue as well as the stimulation of tissue regeneration. Due to the great potentiality of such approach, drug-releasing scaffolds were fabricated from hydrolytically degradable polymers. Three copolymers of poly(ethylene glycol), ɛ-caprolactone, L- and D,L-lactide were synthesized and blended with bone-growth inducing active agents, dexamethasone (DM) and 2-phospho-L-ascorbic acid trisodium salt (AS). Porous scaffolds were prepared by means of super-critical carbon dioxide foaming. In the final scaffold structures, the particle size, location and the water solubility of the drug affected the release kinetics. As the large and water soluble AS particles were more exposed to the buffer solution compared to small DM particles, the AS release was burst-like whereas DM showed a long-term release. The material structure had a significant effect on the release kinetics as the porous scaffolds released active agents faster compared to the solid cylinders. Furthermore, this study showed the strong effect of polymer degradation and wettability on the release, which were more determinative than the pore architecture.

AB - The ability to release active agents from a porous scaffold structure in situ enables the simultaneous structural support for the cells proliferating and differentiating towards tissue as well as the stimulation of tissue regeneration. Due to the great potentiality of such approach, drug-releasing scaffolds were fabricated from hydrolytically degradable polymers. Three copolymers of poly(ethylene glycol), ɛ-caprolactone, L- and D,L-lactide were synthesized and blended with bone-growth inducing active agents, dexamethasone (DM) and 2-phospho-L-ascorbic acid trisodium salt (AS). Porous scaffolds were prepared by means of super-critical carbon dioxide foaming. In the final scaffold structures, the particle size, location and the water solubility of the drug affected the release kinetics. As the large and water soluble AS particles were more exposed to the buffer solution compared to small DM particles, the AS release was burst-like whereas DM showed a long-term release. The material structure had a significant effect on the release kinetics as the porous scaffolds released active agents faster compared to the solid cylinders. Furthermore, this study showed the strong effect of polymer degradation and wettability on the release, which were more determinative than the pore architecture.

KW - 2-Phospho-L-ascorbic acid trisodium salt

KW - Bulk degradation

KW - Dexamethasone

KW - Drug release

KW - Hydrolytic degradation

KW - Supercritical carbon dioxide foaming

U2 - 10.1016/j.eurpolymj.2019.01.056

DO - 10.1016/j.eurpolymj.2019.01.056

M3 - Article

VL - 113

SP - 165

EP - 175

JO - European Polymer Jounal

JF - European Polymer Jounal

SN - 0014-3057

ER -