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Hydrolytic degradation of composites of poly(L-lactide-co-epsilon-caprolactone) 70/30 and beta-tricalcium phosphate

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Translated title of the contributionHydrolytic degradation of composites of poly(L-lactide-co-epsilon-caprolactone) 70/30 and beta-tricalcium phosphate
Original languageEnglish
Pages (from-to)529-543
JournalJournal of Biomaterials Applications
Volume28
Issue number4
DOIs
Publication statusPublished - 2013
Publication typeA1 Journal article-refereed

Abstract

There is an increasing need for synthetic bone substitute materials that decrease the need for allografts and autografts. In this study, composites of β-TCP and a biodegradable poly(L-lactide-co-ε-caprolactone) were manufactured using extrusion to form biodegradable composites with high β-TCP contents for osteoconductivity. The hydrolytic degradation of the composites containing 0, 10, 20, 35 and 50% of β-TCP was studied in vitro for 52 weeks. During the study, it was observed that β-TCP did not have an effect on the degradation rate of the polymer matrix. However, the crystallinity of the materials increased throughout the test series and changes in Tgs were also observed as the comonomer ratio of the polymer matrix changed as the degradation proceeded. The results show that the materials have desirable degradation properties and, thus, possess great potential as bioabsorbable and osteoconductive bone filling materials.

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Field of science, Statistics Finland

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