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In vitro degradation of borosilicate bioactive glass and poly(L-lactide-co-ε-caprolactone) composite scaffolds

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In vitro degradation of borosilicate bioactive glass and poly(L-lactide-co-ε-caprolactone) composite scaffolds. / Tainio, Jenna; Paakinaho, Kaarlo; Ahola, Niina; Hannula, Markus; Hyttinen, Jari; Kellomäki, Minna; Massera, Jonathan.

In: Materials, Vol. 10, 1274, 12.2017.

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@article{fcf498e271af44f0a05eccfe1b3e75cd,
title = "In vitro degradation of borosilicate bioactive glass and poly(L-lactide-co-ε-caprolactone) composite scaffolds",
abstract = "Composite scaffolds were obtained by mixing various amounts (10, 30 and 50 weight {\%} [wt {\%}]) of borosilicate bioactive glass and poly(l-lactide-co-ε-caprolactone) (PLCL) copolymer. The composites were foamed using supercritical CO₂. An increase in the glass content led to a decrease in the pore size and density. In vitro dissolution/reaction test was performed in simulated body fluid. As a function of immersion time, the solution pH increased due to the glass dissolution. This was further supported by the increasing amount of Ca in the immersing solution with increasing immersion time and glass content. Furthermore, the change in scaffold mass was significantly greater with increasing the glass content in the scaffold. However, only the scaffolds containing 30 and 50 wt {\%} of glasses exhibited significant hydroxyapatite (HA) formation at 72 h of immersion. The compression strength of the samples was also measured. The Young's modulus was similar for the 10 and 30 wt {\%} glass-containing scaffolds whereas it increased to 90 MPa for the 50 wt {\%} glass containing scaffold. Upon immersion up to 72 h, the Young's modulus increased and then remained constant for longer immersion times. The scaffold prepared could have great potential for bone and cartilage regeneration.",
author = "Jenna Tainio and Kaarlo Paakinaho and Niina Ahola and Markus Hannula and Jari Hyttinen and Minna Kellom{\"a}ki and Jonathan Massera",
year = "2017",
month = "12",
doi = "10.3390/ma10111274",
language = "English",
volume = "10",
journal = "Materials",
issn = "1996-1944",
publisher = "MDPI AG",

}

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TY - JOUR

T1 - In vitro degradation of borosilicate bioactive glass and poly(L-lactide-co-ε-caprolactone) composite scaffolds

AU - Tainio, Jenna

AU - Paakinaho, Kaarlo

AU - Ahola, Niina

AU - Hannula, Markus

AU - Hyttinen, Jari

AU - Kellomäki, Minna

AU - Massera, Jonathan

PY - 2017/12

Y1 - 2017/12

N2 - Composite scaffolds were obtained by mixing various amounts (10, 30 and 50 weight % [wt %]) of borosilicate bioactive glass and poly(l-lactide-co-ε-caprolactone) (PLCL) copolymer. The composites were foamed using supercritical CO₂. An increase in the glass content led to a decrease in the pore size and density. In vitro dissolution/reaction test was performed in simulated body fluid. As a function of immersion time, the solution pH increased due to the glass dissolution. This was further supported by the increasing amount of Ca in the immersing solution with increasing immersion time and glass content. Furthermore, the change in scaffold mass was significantly greater with increasing the glass content in the scaffold. However, only the scaffolds containing 30 and 50 wt % of glasses exhibited significant hydroxyapatite (HA) formation at 72 h of immersion. The compression strength of the samples was also measured. The Young's modulus was similar for the 10 and 30 wt % glass-containing scaffolds whereas it increased to 90 MPa for the 50 wt % glass containing scaffold. Upon immersion up to 72 h, the Young's modulus increased and then remained constant for longer immersion times. The scaffold prepared could have great potential for bone and cartilage regeneration.

AB - Composite scaffolds were obtained by mixing various amounts (10, 30 and 50 weight % [wt %]) of borosilicate bioactive glass and poly(l-lactide-co-ε-caprolactone) (PLCL) copolymer. The composites were foamed using supercritical CO₂. An increase in the glass content led to a decrease in the pore size and density. In vitro dissolution/reaction test was performed in simulated body fluid. As a function of immersion time, the solution pH increased due to the glass dissolution. This was further supported by the increasing amount of Ca in the immersing solution with increasing immersion time and glass content. Furthermore, the change in scaffold mass was significantly greater with increasing the glass content in the scaffold. However, only the scaffolds containing 30 and 50 wt % of glasses exhibited significant hydroxyapatite (HA) formation at 72 h of immersion. The compression strength of the samples was also measured. The Young's modulus was similar for the 10 and 30 wt % glass-containing scaffolds whereas it increased to 90 MPa for the 50 wt % glass containing scaffold. Upon immersion up to 72 h, the Young's modulus increased and then remained constant for longer immersion times. The scaffold prepared could have great potential for bone and cartilage regeneration.

U2 - 10.3390/ma10111274

DO - 10.3390/ma10111274

M3 - Article

VL - 10

JO - Materials

JF - Materials

SN - 1996-1944

M1 - 1274

ER -