Increased Binding of Calcium Ions at Positively Curved Phospholipid Membranes
Research output: Contribution to journal › Article › Scientific › peer-review
|Number of pages||6|
|Journal||Journal of Physical Chemistry Letters|
|Publication status||Published - 19 Jan 2017|
|Publication type||A1 Journal article-refereed|
Calcium ion is the ubiquitous messenger in cells and plays a key role in neuronal signaling and fusion of synaptic vesicles. These vesicles are typically ∼20-50 nm in diameter, and thus their interaction with calcium ions cannot be modeled faithfully with a conventional flat membrane bilayer setup. Within our newly developed molecular dynamics simulations setup, we characterize here interactions of the calcium ion with curved membrane interfaces with atomistic detail. The present molecular dynamics simulations together with time-dependent fluorescence shift experiments suggest that the mode and strength of interaction of calcium ion with a phospholipid bilayer depends on its curvature. Potential of mean force calculations demonstrate that the binding of calcium ion to the positively curved side of the bilayer is significantly stronger compared with that to a flat membrane.