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Inner ear barriers to nanomedicine-augmented drug delivery and imaging

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Inner ear barriers to nanomedicine-augmented drug delivery and imaging. / Zou, Jing; Pyykkö, Ilmari; Hyttinen, Jari.

In: Journal of Otology, Vol. 11, No. 4, 2016, p. 165-177.

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Zou, Jing ; Pyykkö, Ilmari ; Hyttinen, Jari. / Inner ear barriers to nanomedicine-augmented drug delivery and imaging. In: Journal of Otology. 2016 ; Vol. 11, No. 4. pp. 165-177.

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@article{e3975e37b844470cb15f37d2e1d783b9,
title = "Inner ear barriers to nanomedicine-augmented drug delivery and imaging",
abstract = "Abstract There are several challenges to inner ear drug delivery and imaging due to the existence of tight biological barriers to the target structure and the dense bone surrounding it. Advances in imaging and nanomedicine may provide knowledge for overcoming the existing limitations to both the diagnosis and treatment of inner ear diseases. Novel techniques have improved the efficacy of drug delivery and targeting to the inner ear, as well as the quality and accuracy of imaging this structure. In this review, we will describe the pathways and biological barriers of the inner ear regarding drug delivery, the beneficial applications and limitations of the imaging techniques available for inner ear research, the behavior of engineered nanomaterials in inner ear applications, and future perspectives for nanomedicine-based inner ear imaging.",
keywords = "Inner ear, medicine, nanotechnology, imaging, targeting, gene delivery, contrast agents",
author = "Jing Zou and Ilmari Pyykk{\"o} and Jari Hyttinen",
year = "2016",
doi = "10.1016/j.joto.2016.11.002",
language = "English",
volume = "11",
pages = "165--177",
journal = "Journal of Otology",
issn = "1672-2930",
publisher = "PLA General Hospital Department of Otolaryngology Head and Neck Surgery",
number = "4",

}

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TY - JOUR

T1 - Inner ear barriers to nanomedicine-augmented drug delivery and imaging

AU - Zou, Jing

AU - Pyykkö, Ilmari

AU - Hyttinen, Jari

PY - 2016

Y1 - 2016

N2 - Abstract There are several challenges to inner ear drug delivery and imaging due to the existence of tight biological barriers to the target structure and the dense bone surrounding it. Advances in imaging and nanomedicine may provide knowledge for overcoming the existing limitations to both the diagnosis and treatment of inner ear diseases. Novel techniques have improved the efficacy of drug delivery and targeting to the inner ear, as well as the quality and accuracy of imaging this structure. In this review, we will describe the pathways and biological barriers of the inner ear regarding drug delivery, the beneficial applications and limitations of the imaging techniques available for inner ear research, the behavior of engineered nanomaterials in inner ear applications, and future perspectives for nanomedicine-based inner ear imaging.

AB - Abstract There are several challenges to inner ear drug delivery and imaging due to the existence of tight biological barriers to the target structure and the dense bone surrounding it. Advances in imaging and nanomedicine may provide knowledge for overcoming the existing limitations to both the diagnosis and treatment of inner ear diseases. Novel techniques have improved the efficacy of drug delivery and targeting to the inner ear, as well as the quality and accuracy of imaging this structure. In this review, we will describe the pathways and biological barriers of the inner ear regarding drug delivery, the beneficial applications and limitations of the imaging techniques available for inner ear research, the behavior of engineered nanomaterials in inner ear applications, and future perspectives for nanomedicine-based inner ear imaging.

KW - Inner ear

KW - medicine

KW - nanotechnology

KW - imaging

KW - targeting

KW - gene delivery

KW - contrast agents

U2 - 10.1016/j.joto.2016.11.002

DO - 10.1016/j.joto.2016.11.002

M3 - Article

VL - 11

SP - 165

EP - 177

JO - Journal of Otology

JF - Journal of Otology

SN - 1672-2930

IS - 4

ER -