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Interactions of molecular ions with model phospholipid membranes

Research output: Contribution to journalArticleScientificpeer-review


Original languageEnglish
Pages (from-to)695-711
Number of pages17
JournalCollection of Czechoslovak Chemical Communications
Issue number6
Publication statusPublished - 2011
Publication typeA1 Journal article-refereed


The affinities of a series of biologically relevant ions for a hydrated phospholipid membrane were investigated using molecular dynamics simulation. Interactions of molecular ions, such as guanidinium, tetramethylammonium, and thiocyanate with the bilayer were computationally characterized for the first time. Simulations reveal strong ion specificity. On one hand, ions like guanidinium and thiocyanate adsorb relatively strongly to the headgroup region of the membrane. On the other hand, potassium or chloride interact very weakly with the phospholipids and merely act as neutralizing counterions. Calculations also show that these ions affect differently biophysical properties of the membrane, such as lipid diffusion, headgroup hydration and tilt angle.

ASJC Scopus subject areas


  • Biophysics, Molecular dynamics, Phospholipids