Intramolecular C-H insertion catalyzed by dirhodium(II) complexes using CO2 as the reaction media
Research output: Contribution to journal › Article › Scientific › peer-review
|Number of pages||30|
|Journal||Green Chemistry Letters and Reviews|
|Publication status||Published - 2012|
|Publication type||A1 Journal article-refereed|
In this work, the intramolecular C-H insertion of diazoacetamides catalyzed by dirhodium(II) complexes and using CO2 as solvent is disclosed. The expected lactams were obtained in yields over 97%. The asymmetric intramolecular C-H insertion was also achieved and the beta-lactam 14 was obtained in > 97% yield and 65% ee using the chiral dirhodium(II) catalyst Rh-2(S-PTTL)(4). Finally, the dirhodium(II) complex Rh-2(OAc)(4) was used in two consecutive cycles in which complete conversion to the lactam was observed.
- diazoacetamides, C-H insertion, dirhodium(II), lactams, scCO(2), ASYMMETRIC CYCLOPROPANATION, ALPHA-DIAZOACETAMIDES, HOMOGENEOUS CATALYSIS, SUPERCRITICAL FLUIDS, CARBOXYLATES, ENANTIOSELECTIVITY, TRANSFORMATIONS, IMMOBILIZATION, ACTIVATION, STRATEGY