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Intrinsic Complexity of RR and QT Intervals at the Cellular Level

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Original languageEnglish
Number of pages4
JournalComputing in Cardiology
Publication statusPublished - 2018
Publication typeA1 Journal article-refereed


We characterize the complexity of interbeat intervals (IBIs) and field potential durations (FPDs) of human-induced plurioptent stem cell-derived cardiomyocytes
(hiPSC-CMs). The complexity is assessed using the multiscale entropy (MSE) method up to the scale of ten beats. The MSE profiles of healthy and diseased (long-QT syndrome) hiPSC-CMs show important differences, which demonstrate the usefulness of the method in the characterization of the cells and in the analysis of hereditary cardiac diseases. We show that the intrinsic complexity is possibly
altered by the differentiation methods, as well as the age and mutations of the cells.

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Field of science, Statistics Finland

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