Iterative reconstruction method based on median root prior in quantification with PET
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review
|Title of host publication||Positron Emission Tomography in the Millennium|
|Editors||N Tamaki, E Tsukamoto, Y Kuge, C Katoh, K Morita|
|Place of Publication||Amsterdam|
|Publisher||Elsevier Science Publishers B.V.|
|Number of pages||6|
|Publication status||Published - 2000|
|Publication type||A4 Article in a conference publication|
|Event||International Positron Emission Tomography Symposium (PET) - SAPPORO, Japan|
Duration: 24 Sep 1999 → 26 Sep 1999
|Name||INTERNATIONAL CONGRESS SERIES|
|Publisher||ELSEVIER SCIENCE BV|
|Conference||International Positron Emission Tomography Symposium (PET)|
|Period||24/09/99 → 26/09/99|
The aim of this study was to compare reproducibility and accuracy of two reconstruction methods in quantification of regional myocardial blood flow (rMBF) and oxygen metabolism with [O-15] labeled tracers and positron emission tomography (PET). A new iterative Bayesian reconstruction method based on median root prior (MRP) was compared with filtered back-projection (FBP) method.
Methods, rMBF, oxygen extraction fraction (rOEF) and myocardial metabolic rate of oxygen consumption (rMMRO(2)) were quantified from images reconstructed using both MRP and FBP in 27 subjects. For each subject, regions of interest (ROIs) were drawn on the lateral, anterior and septal regions on four planes. To test the reproducibility, the ROI drawing procedure was repeated. Using two sets of ROIs, variability was evaluated with MRP and FBP images.
Results. Correlation coefficients of rMBF rOEF and rMMRO(2) were significantly higher in MRP images than in FBP images. Coefficient of variations for each parameter was significantly lower in MRP images than in FBP.
Conclusion. MRP reconstruction provides higher reproducibility and lower variability in the quantitative myocardial parameters compared with FBP. This study presents that the new MRP reconstruction improves accuracy and stability of clinical quantification of myocardial blood flow and oxygen metabolism with [O-15] and PET.
- Bayesian reconstruction, metabolic rate of oxygen consumption, myocardial blood flow, POSITRON-EMISSION TOMOGRAPHY, MYOCARDIAL BLOOD-FLOW, INHALATION