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Iterative reconstruction method based on median root prior in quantification with PET

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review


Original languageEnglish
Title of host publicationPositron Emission Tomography in the Millennium
EditorsN Tamaki, E Tsukamoto, Y Kuge, C Katoh, K Morita
Place of PublicationAmsterdam
PublisherElsevier Science Publishers B.V.
Number of pages6
ISBN (Print)0-444-50385-4
Publication statusPublished - 2000
Externally publishedYes
Publication typeA4 Article in a conference publication
EventInternational Positron Emission Tomography Symposium (PET) - SAPPORO, Japan
Duration: 24 Sep 199926 Sep 1999

Publication series

ISSN (Print)0531-5131


ConferenceInternational Positron Emission Tomography Symposium (PET)


The aim of this study was to compare reproducibility and accuracy of two reconstruction methods in quantification of regional myocardial blood flow (rMBF) and oxygen metabolism with [O-15] labeled tracers and positron emission tomography (PET). A new iterative Bayesian reconstruction method based on median root prior (MRP) was compared with filtered back-projection (FBP) method.

Methods, rMBF, oxygen extraction fraction (rOEF) and myocardial metabolic rate of oxygen consumption (rMMRO(2)) were quantified from images reconstructed using both MRP and FBP in 27 subjects. For each subject, regions of interest (ROIs) were drawn on the lateral, anterior and septal regions on four planes. To test the reproducibility, the ROI drawing procedure was repeated. Using two sets of ROIs, variability was evaluated with MRP and FBP images.

Results. Correlation coefficients of rMBF rOEF and rMMRO(2) were significantly higher in MRP images than in FBP images. Coefficient of variations for each parameter was significantly lower in MRP images than in FBP.

Conclusion. MRP reconstruction provides higher reproducibility and lower variability in the quantitative myocardial parameters compared with FBP. This study presents that the new MRP reconstruction improves accuracy and stability of clinical quantification of myocardial blood flow and oxygen metabolism with [O-15] and PET.


  • Bayesian reconstruction, metabolic rate of oxygen consumption, myocardial blood flow, POSITRON-EMISSION TOMOGRAPHY, MYOCARDIAL BLOOD-FLOW, INHALATION