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Longitudinal assessment of clinically isolated syndrome with diffusion tensor imaging and volumetric MRI

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Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalClinical Imaging
Issue number2
Publication statusPublished - 1 Mar 2015
Publication typeA1 Journal article-refereed


The potential of diffusion tensor imaging (DTI) indices and volumes of focal lesions on conventional magnetic resonance imaging to predict conversion to multiple sclerosis (MS) was analyzed in subjects with clinically isolated syndrome (CIS) over 4 years. Twenty patients with CIS and 10 healthy controls were included in the study. The data showed an association between the volumes of T1 and fluid-attenuated inversion recovery (FLAIR) lesions and conversion to MS (T1: P= .02; FLAIR: P= .02). The worsening of DTI indices (mean diffusivity and fractional anisotropy) was primarily seen in patients progressing to MS, but clear-cut association with conversion could not be detected.


  • Clinically isolated syndrome, Diffusion tensor, Normal-appearing gray matter, Normal-appearing white matter, Volume measurements

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Field of science, Statistics Finland