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Modeling of Neuronal Growth In Vitro: Comparison of Simulation Tools NETMORPH and CX3D

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Details

Original languageEnglish
Article number616382
Pages (from-to)1-13
Number of pages13
JournalEurasip Journal on Bioinformatics and Systems Biology
Volume2011
DOIs
Publication statusPublished - 2011
Publication typeA1 Journal article-refereed

Abstract

We simulate the growth of neuronal networks using the two recently published tools, NETMORPH and CX3D. The goals of the work are (1) to examine and compare the simulation tools, (2) to construct a model of growth of neocortical cultures, and (3) to characterize the changes in network connectivity during growth, using standard graph theoretic methods. Parameters for the neocortical culture are chosen after consulting both the experimental and the computational work presented in the literature. The first (three) weeks in culture are known to be a time of development of extensive dendritic and axonal arbors and establishment of synaptic connections between the neurons. We simulate the growth of networks from day 1 to day 21. It is shown that for the properly selected parameters, the simulators can reproduce the experimentally obtained connectivity. The selected graph theoretic methods can capture the structural changes during growth.

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Field of science, Statistics Finland

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