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Molecular Communications Pulse-based Jamming Model for Bacterial Biofilm Suppression

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Molecular Communications Pulse-based Jamming Model for Bacterial Biofilm Suppression. / Martins, Daniel P.; Leetanasaksakul, Kantinan; Barros, Michael Taynnan; Thamchaipenet, Arinthip; Donnelly, William; Balasubramaniam, Sasitharan.

In: IEEE Transactions on Nanobioscience, Vol. 17, No. 4, 10.2018, p. 533-542.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Martins, DP, Leetanasaksakul, K, Barros, MT, Thamchaipenet, A, Donnelly, W & Balasubramaniam, S 2018, 'Molecular Communications Pulse-based Jamming Model for Bacterial Biofilm Suppression', IEEE Transactions on Nanobioscience, vol. 17, no. 4, pp. 533-542. https://doi.org/10.1109/TNB.2018.2871276

APA

Martins, D. P., Leetanasaksakul, K., Barros, M. T., Thamchaipenet, A., Donnelly, W., & Balasubramaniam, S. (2018). Molecular Communications Pulse-based Jamming Model for Bacterial Biofilm Suppression. IEEE Transactions on Nanobioscience, 17(4), 533-542. https://doi.org/10.1109/TNB.2018.2871276

Vancouver

Martins DP, Leetanasaksakul K, Barros MT, Thamchaipenet A, Donnelly W, Balasubramaniam S. Molecular Communications Pulse-based Jamming Model for Bacterial Biofilm Suppression. IEEE Transactions on Nanobioscience. 2018 Oct;17(4):533-542. https://doi.org/10.1109/TNB.2018.2871276

Author

Martins, Daniel P. ; Leetanasaksakul, Kantinan ; Barros, Michael Taynnan ; Thamchaipenet, Arinthip ; Donnelly, William ; Balasubramaniam, Sasitharan. / Molecular Communications Pulse-based Jamming Model for Bacterial Biofilm Suppression. In: IEEE Transactions on Nanobioscience. 2018 ; Vol. 17, No. 4. pp. 533-542.

Bibtex - Download

@article{b90e9da2f9f24218ae316e112324b334,
title = "Molecular Communications Pulse-based Jamming Model for Bacterial Biofilm Suppression",
abstract = "Studies have recently shown that the bacteria survivability within biofilms is responsible for the emergence of superbugs. The combat of bacterial infections, without enhancing its resistance to antibiotics, includes the use of nanoparticles to quench the quorum sensing of these biofilm-forming bacteria. Several sequential and parallel multi-stage communication processes are involved in the formation of biofilms. In this paper, we use proteomic data from a wet lab experiment to identify the communication channels that are vital to these processes.We also identified the main proteins from each channel and propose the use of jamming signals from synthetically engineered bacteria to suppress the production of those proteins. This biocompatible technique is based on synthetic biology and enables the inhibition of biofilm formation. We analyse the communications performance of the jamming process, by evaluating the path loss for a number of conditions that include different engineered bacterial population sizes, distances between the populations and molecular signal power. Our results show that sufficient molecular pulsebased jamming signals are able to prevent the biofilm formation by creating lossy communications channels (almost -3 dB for certain scenarios). From these results, we define the main design parameters to develop a fully operational bacteria-based jamming system.",
keywords = "Biofilm suppression, Communications systems, Jamming, Synthetic logic circuits",
author = "Martins, {Daniel P.} and Kantinan Leetanasaksakul and Barros, {Michael Taynnan} and Arinthip Thamchaipenet and William Donnelly and Sasitharan Balasubramaniam",
year = "2018",
month = "10",
doi = "10.1109/TNB.2018.2871276",
language = "English",
volume = "17",
pages = "533--542",
journal = "IEEE Transactions on Nanobioscience",
issn = "1536-1241",
publisher = "Institute of Electrical and Electronics Engineers",
number = "4",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Molecular Communications Pulse-based Jamming Model for Bacterial Biofilm Suppression

AU - Martins, Daniel P.

AU - Leetanasaksakul, Kantinan

AU - Barros, Michael Taynnan

AU - Thamchaipenet, Arinthip

AU - Donnelly, William

AU - Balasubramaniam, Sasitharan

PY - 2018/10

Y1 - 2018/10

N2 - Studies have recently shown that the bacteria survivability within biofilms is responsible for the emergence of superbugs. The combat of bacterial infections, without enhancing its resistance to antibiotics, includes the use of nanoparticles to quench the quorum sensing of these biofilm-forming bacteria. Several sequential and parallel multi-stage communication processes are involved in the formation of biofilms. In this paper, we use proteomic data from a wet lab experiment to identify the communication channels that are vital to these processes.We also identified the main proteins from each channel and propose the use of jamming signals from synthetically engineered bacteria to suppress the production of those proteins. This biocompatible technique is based on synthetic biology and enables the inhibition of biofilm formation. We analyse the communications performance of the jamming process, by evaluating the path loss for a number of conditions that include different engineered bacterial population sizes, distances between the populations and molecular signal power. Our results show that sufficient molecular pulsebased jamming signals are able to prevent the biofilm formation by creating lossy communications channels (almost -3 dB for certain scenarios). From these results, we define the main design parameters to develop a fully operational bacteria-based jamming system.

AB - Studies have recently shown that the bacteria survivability within biofilms is responsible for the emergence of superbugs. The combat of bacterial infections, without enhancing its resistance to antibiotics, includes the use of nanoparticles to quench the quorum sensing of these biofilm-forming bacteria. Several sequential and parallel multi-stage communication processes are involved in the formation of biofilms. In this paper, we use proteomic data from a wet lab experiment to identify the communication channels that are vital to these processes.We also identified the main proteins from each channel and propose the use of jamming signals from synthetically engineered bacteria to suppress the production of those proteins. This biocompatible technique is based on synthetic biology and enables the inhibition of biofilm formation. We analyse the communications performance of the jamming process, by evaluating the path loss for a number of conditions that include different engineered bacterial population sizes, distances between the populations and molecular signal power. Our results show that sufficient molecular pulsebased jamming signals are able to prevent the biofilm formation by creating lossy communications channels (almost -3 dB for certain scenarios). From these results, we define the main design parameters to develop a fully operational bacteria-based jamming system.

KW - Biofilm suppression

KW - Communications systems

KW - Jamming

KW - Synthetic logic circuits

U2 - 10.1109/TNB.2018.2871276

DO - 10.1109/TNB.2018.2871276

M3 - Article

VL - 17

SP - 533

EP - 542

JO - IEEE Transactions on Nanobioscience

JF - IEEE Transactions on Nanobioscience

SN - 1536-1241

IS - 4

ER -