Molecular Design of Light-Responsive Hydrogels, for in Situ Generation of Fast and Reversible Valves for Microfluidic Applications

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Molecular Design of Light-Responsive Hydrogels, for in Situ Generation of Fast and Reversible Valves for Microfluidic Applications. / Ter Schiphorst, Jeroen; Coleman, Simon; Stumpel, Jelle E.; Ben Azouz, Aymen; Diamond, Dermot; Schenning, Albertus P. H. J.

In: Chemistry of Materials, Vol. 27, No. 17, 08.09.2015, p. 5925-5931.

Research output: Contribution to journal › Article › Scientific › peer-review

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Ter Schiphorst, Jeroen ; Coleman, Simon ; Stumpel, Jelle E. ; Ben Azouz, Aymen ; Diamond, Dermot ; Schenning, Albertus P. H. J. / Molecular Design of Light-Responsive Hydrogels, for in Situ Generation of Fast and Reversible Valves for Microfluidic Applications. In: Chemistry of Materials. 2015 ; Vol. 27, No. 17. pp. 5925-5931.

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@article{4241a0785f9747a685c71a4a5fa57c25,

title = "Molecular Design of Light-Responsive Hydrogels, for in Situ Generation of Fast and Reversible Valves for Microfluidic Applications",

abstract = "Reversible light-responsive hydrogel valves with response characteristics compatible for microfluidics have been obtained by optimization of molecular design of spiropyran photoswitches and gel composition. Self-protonating gel formulations were exploited, wherein acrylic acid was copolymerized in the hydrogel network as an internal proton donor, to achieve a swollen state of the hydrogel in water at neutral pH. Light-responsive properties were endowed upon the hydrogels by copolymerization of spiropyran chromophores, using electron withdrawing and donating groups to tune the gel-swelling and shrinkage behavior. In all cases, the shrinkage was determined by the water diffusion rate, while for the swelling the isomerization kinetics is the rate-determining step. For one hydrogel, reversible and reproducible volume changes were observed. Finally, gel-valves integrated within microfluidic channels were fabricated, allowing reversible and repeatable operation, with opening and closing of the valve in minutes.",

author = "{Ter Schiphorst}, Jeroen and Simon Coleman and Stumpel, {Jelle E.} and {Ben Azouz}, Aymen and Dermot Diamond and Schenning, {Albertus P. H. J.}",

year = "2015",

month = "9",

day = "8",

doi = "10.1021/acs.chemmater.5b01860",

language = "English",

volume = "27",

pages = "5925--5931",

journal = "Chemistry of Materials",

issn = "0897-4756",

publisher = "American Chemical Society",

number = "17",

}

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TY - JOUR

T1 - Molecular Design of Light-Responsive Hydrogels, for in Situ Generation of Fast and Reversible Valves for Microfluidic Applications

AU - Ter Schiphorst, Jeroen

AU - Coleman, Simon

AU - Stumpel, Jelle E.

AU - Ben Azouz, Aymen

AU - Diamond, Dermot

AU - Schenning, Albertus P. H. J.

PY - 2015/9/8

Y1 - 2015/9/8

N2 - Reversible light-responsive hydrogel valves with response characteristics compatible for microfluidics have been obtained by optimization of molecular design of spiropyran photoswitches and gel composition. Self-protonating gel formulations were exploited, wherein acrylic acid was copolymerized in the hydrogel network as an internal proton donor, to achieve a swollen state of the hydrogel in water at neutral pH. Light-responsive properties were endowed upon the hydrogels by copolymerization of spiropyran chromophores, using electron withdrawing and donating groups to tune the gel-swelling and shrinkage behavior. In all cases, the shrinkage was determined by the water diffusion rate, while for the swelling the isomerization kinetics is the rate-determining step. For one hydrogel, reversible and reproducible volume changes were observed. Finally, gel-valves integrated within microfluidic channels were fabricated, allowing reversible and repeatable operation, with opening and closing of the valve in minutes.

AB - Reversible light-responsive hydrogel valves with response characteristics compatible for microfluidics have been obtained by optimization of molecular design of spiropyran photoswitches and gel composition. Self-protonating gel formulations were exploited, wherein acrylic acid was copolymerized in the hydrogel network as an internal proton donor, to achieve a swollen state of the hydrogel in water at neutral pH. Light-responsive properties were endowed upon the hydrogels by copolymerization of spiropyran chromophores, using electron withdrawing and donating groups to tune the gel-swelling and shrinkage behavior. In all cases, the shrinkage was determined by the water diffusion rate, while for the swelling the isomerization kinetics is the rate-determining step. For one hydrogel, reversible and reproducible volume changes were observed. Finally, gel-valves integrated within microfluidic channels were fabricated, allowing reversible and repeatable operation, with opening and closing of the valve in minutes.

UR - http://www.scopus.com/inward/record.url?scp=84941088068&partnerID=8YFLogxK

U2 - 10.1021/acs.chemmater.5b01860

DO - 10.1021/acs.chemmater.5b01860

M3 - Article

VL - 27

SP - 5925

EP - 5931

JO - Chemistry of Materials

JF - Chemistry of Materials

SN - 0897-4756

IS - 17

ER -

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