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Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice

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Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. / Kainulainen, Heikki; Papaioannou, Konstantinos G.; Silvennoinen, Mika; Autio, Reija; Saarela, Janne; Oliveira, Bernardo M.; Nyqvist, Miro; Pasternack, Arja; Hoen, Peter A.C. ´t; Kujala, Urho M.; Ritvos, Olli; Hulmi, Juha J.

In: Molecular and Cellular Endocrinology, Vol. 399, 2015, p. 131-142.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Kainulainen, H, Papaioannou, KG, Silvennoinen, M, Autio, R, Saarela, J, Oliveira, BM, Nyqvist, M, Pasternack, A, Hoen, PAC, Kujala, UM, Ritvos, O & Hulmi, JJ 2015, 'Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice', Molecular and Cellular Endocrinology, vol. 399, pp. 131-142. https://doi.org/10.1016/j.mce.2014.10.001

APA

Kainulainen, H., Papaioannou, K. G., Silvennoinen, M., Autio, R., Saarela, J., Oliveira, B. M., ... Hulmi, J. J. (2015). Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. Molecular and Cellular Endocrinology, 399, 131-142. https://doi.org/10.1016/j.mce.2014.10.001

Vancouver

Kainulainen H, Papaioannou KG, Silvennoinen M, Autio R, Saarela J, Oliveira BM et al. Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. Molecular and Cellular Endocrinology. 2015;399:131-142. https://doi.org/10.1016/j.mce.2014.10.001

Author

Kainulainen, Heikki ; Papaioannou, Konstantinos G. ; Silvennoinen, Mika ; Autio, Reija ; Saarela, Janne ; Oliveira, Bernardo M. ; Nyqvist, Miro ; Pasternack, Arja ; Hoen, Peter A.C. ´t ; Kujala, Urho M. ; Ritvos, Olli ; Hulmi, Juha J. / Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. In: Molecular and Cellular Endocrinology. 2015 ; Vol. 399. pp. 131-142.

Bibtex - Download

@article{a2ad3884674e405e9384dcecf9a18327,
title = "Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice",
abstract = "Duchenne muscular dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for 7 weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However, exercise activated pathways of aerobic metabolism and counteracted the negative effects of sActRIIB-Fc. Exercise and sActRIIB-Fc synergistically increased expression of major urinary protein, but exercise blocked sActRIIB-Fc induced phosphorylation of STAT5 in gastrocnemius muscle. In conclusion, exercise alone or in combination with myostatin/activin blocking corrects aerobic gene expression profiles of dystrophic muscle toward healthy wild type mice profiles.",
author = "Heikki Kainulainen and Papaioannou, {Konstantinos G.} and Mika Silvennoinen and Reija Autio and Janne Saarela and Oliveira, {Bernardo M.} and Miro Nyqvist and Arja Pasternack and Hoen, {Peter A.C. ´t} and Kujala, {Urho M.} and Olli Ritvos and Hulmi, {Juha J.}",
note = "Contribution: organisation=sgn,FACT1=1<br/>Portfolio EDEND: 2015-01-13<br/>Publisher name: Elsevier",
year = "2015",
doi = "10.1016/j.mce.2014.10.001",
language = "English",
volume = "399",
pages = "131--142",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Myostatin/ activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice

AU - Kainulainen, Heikki

AU - Papaioannou, Konstantinos G.

AU - Silvennoinen, Mika

AU - Autio, Reija

AU - Saarela, Janne

AU - Oliveira, Bernardo M.

AU - Nyqvist, Miro

AU - Pasternack, Arja

AU - Hoen, Peter A.C. ´t

AU - Kujala, Urho M.

AU - Ritvos, Olli

AU - Hulmi, Juha J.

N1 - Contribution: organisation=sgn,FACT1=1<br/>Portfolio EDEND: 2015-01-13<br/>Publisher name: Elsevier

PY - 2015

Y1 - 2015

N2 - Duchenne muscular dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for 7 weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However, exercise activated pathways of aerobic metabolism and counteracted the negative effects of sActRIIB-Fc. Exercise and sActRIIB-Fc synergistically increased expression of major urinary protein, but exercise blocked sActRIIB-Fc induced phosphorylation of STAT5 in gastrocnemius muscle. In conclusion, exercise alone or in combination with myostatin/activin blocking corrects aerobic gene expression profiles of dystrophic muscle toward healthy wild type mice profiles.

AB - Duchenne muscular dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for 7 weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However, exercise activated pathways of aerobic metabolism and counteracted the negative effects of sActRIIB-Fc. Exercise and sActRIIB-Fc synergistically increased expression of major urinary protein, but exercise blocked sActRIIB-Fc induced phosphorylation of STAT5 in gastrocnemius muscle. In conclusion, exercise alone or in combination with myostatin/activin blocking corrects aerobic gene expression profiles of dystrophic muscle toward healthy wild type mice profiles.

U2 - 10.1016/j.mce.2014.10.001

DO - 10.1016/j.mce.2014.10.001

M3 - Article

VL - 399

SP - 131

EP - 142

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

ER -