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Neuromuscular pathology in mice lacking alpha-synuclein

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Original languageEnglish
Pages (from-to)350-353
Number of pages4
JournalNeuroscience Letters
Issue number3
Publication statusPublished - 10 Jan 2011
Publication typeA1 Journal article-refereed


This work was undertaken in order to study the possible role of alpha-synuclein in the function of the neuro-muscular junction in skeletal muscles. Repeated stimulation of skeletal muscle motor neurons revealed signs of neuromuscular pathology in alpha-synuclein null mutated (C57Bl/6JOlaHsd) and knockout (B6;129X1-Sncatm1Rosl/J) mice. This stimulation produced repetitive compound muscle action potentials in both lines of alpha-synuclein deficient mice. Muscle strength and muscle coordination during ambulation were unaffected, though motor learning was slower in alpha-synuclein deficient mice in the Rotarod test. We conclude that alpha-synuclein may play a role in acetylcholine compartmentalization at the neuromuscular junction, and in the fine control of activity of skeletal muscles.

ASJC Scopus subject areas


  • Alpha-synuclein, Electromyography, Knockout mice, Neuromuscular junction, Skeletal muscles