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Non-coding RNAs in DNA damage and repair

Research output: Contribution to journalReview ArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)1832-1839
Number of pages8
JournalFEBS Letters
Volume587
Issue number13
DOIs
Publication statusPublished - 27 Jun 2013
Publication typeA2 Review article in a scientific journal

Abstract

Non-coding RNAs (ncRNAs) are increasingly recognized as central players in diverse biological processes. Upon DNA damage, the DNA damage response (DDR) elicits a complex signaling cascade, which includes the induction of multiple ncRNA species. Recent studies indicate that DNA-damage induced ncRNAs contribute to regulation of cell cycle, apoptosis and DNA repair, and thus play a key role in maintaining genome stability. This review summarizes the emerging role of ncRNAs in DNA damage and repair.

Keywords

  • Non-coding RNA DNA damage Repair miRNA Long non-coding RNA Genome integrity