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On the biomaterials for nanostructured ocular therapeutics

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)1443-1459
Number of pages17
JournalCurrent Organic Chemistry
Volume19
Issue number15
Publication statusPublished - 1 Jul 2015
Publication typeA1 Journal article-refereed

Abstract

Due to its unique anatomy, drug delivery to eye structures has always been problematic. Many efforts have been addressed to enhance ocular bioavailability by lowering non-specific interactions between drug and tissue, increasing drug stability or increasing the residence time in the case of topical drugs. In this context, nanotechnology has been a very helpful tool for developing suitable drug delivery systems. More specifically, different kinds of strategies in this field have been proposed to overcome the problems related to ocular administration. However, the success of a nanoparticulated system relies on the correct choice of the material which it is made of. Based on these statements, the present article offers a review of the most important biomaterials employed in nanostructured systems for ocular drug delivery, especially those designated to delivery to the ocular surface and their impact on the final activity of such systems.

ASJC Scopus subject areas

Keywords

  • Biomaterial, Drug delivery, Eye, Nanoparticles, Nanotechnology