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Osteointegration of PLGA implants with nanostructured or microsized β-TCP particles in a minipig model

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Osteointegration of PLGA implants with nanostructured or microsized β-TCP particles in a minipig model. / Kulkova, Julia; Moritz, Niko; Suokas, Esa O.; Strandberg, Niko; Leino, Kari A.; Laitio, Timo T.; Aro, Hannu T.

In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 40, 01.12.2014, p. 190-200.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Kulkova, J, Moritz, N, Suokas, EO, Strandberg, N, Leino, KA, Laitio, TT & Aro, HT 2014, 'Osteointegration of PLGA implants with nanostructured or microsized β-TCP particles in a minipig model', Journal of the Mechanical Behavior of Biomedical Materials, vol. 40, pp. 190-200. https://doi.org/10.1016/j.jmbbm.2014.08.028

APA

Kulkova, J., Moritz, N., Suokas, E. O., Strandberg, N., Leino, K. A., Laitio, T. T., & Aro, H. T. (2014). Osteointegration of PLGA implants with nanostructured or microsized β-TCP particles in a minipig model. Journal of the Mechanical Behavior of Biomedical Materials, 40, 190-200. https://doi.org/10.1016/j.jmbbm.2014.08.028

Vancouver

Kulkova J, Moritz N, Suokas EO, Strandberg N, Leino KA, Laitio TT et al. Osteointegration of PLGA implants with nanostructured or microsized β-TCP particles in a minipig model. Journal of the Mechanical Behavior of Biomedical Materials. 2014 Dec 1;40:190-200. https://doi.org/10.1016/j.jmbbm.2014.08.028

Author

Kulkova, Julia ; Moritz, Niko ; Suokas, Esa O. ; Strandberg, Niko ; Leino, Kari A. ; Laitio, Timo T. ; Aro, Hannu T. / Osteointegration of PLGA implants with nanostructured or microsized β-TCP particles in a minipig model. In: Journal of the Mechanical Behavior of Biomedical Materials. 2014 ; Vol. 40. pp. 190-200.

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@article{61f5ec5e11d542fcb675309d401961a0,
title = "Osteointegration of PLGA implants with nanostructured or microsized β-TCP particles in a minipig model",
abstract = "Bioresorbable suture anchors and interference screws have certain benefits over equivalent titanium-alloy implants. However, there is a need for compositional improvement of currently used bioresorbable implants. We hypothesized that implants made of poly(. l-lactide-co-glycolide) (PLGA) compounded with nanostructured particles of beta-tricalcium phosphate (β-TCP) would induce stronger osteointegration than implants made of PLGA compounded with microsized β-TCP particles. The experimental nanostructured self-reinforced PLGA (85L:15G)/β-TCP composite was made by high-energy ball-milling. Self-reinforced microsized PLGA (95L:5G)/β-TCP composite was prepared by melt-compounding. The composites were characterized by gas chromatography, Ubbelohde viscometry, scanning electron microscopy, laser diffractometry, and standard mechanical tests. Four groups of implants were prepared for the controlled laboratory study employing a minipig animal model. Implants in the first two groups were prepared from nanostructured and microsized PLGA/β-TCP composites respectively. Microroughened titanium-alloy (Ti6Al4V) implants served as positive intra-animal control, and pure PLGA implants as negative control. Cone-shaped implants were inserted in a random order unilaterally in the anterior cortex of the femoral shaft. Eight weeks after surgery, the mechanical strength of osteointegration of the implants was measured by a push-out test. The quality of new bone surrounding the implant was assessed by microcomputed tomography and histology. Implants made of nanostructured PLGA/β-TCP composite did not show improved mechanical osteointegration compared with the implants made of microsized PLGA/β-TCP composite. In the intra-animal comparison, the push-out force of two PLGA/β-TCP composites was 35-60{\%} of that obtained with Ti6Al4V implants. The implant materials did not result in distinct differences in quality of new bone surrounding the implant.",
keywords = "Beta-tricalcium phosphate, Bioresorbable bone implants, Composite, Minipig, Nanostructure, Poly(l-lactide-co-glycolide)",
author = "Julia Kulkova and Niko Moritz and Suokas, {Esa O.} and Niko Strandberg and Leino, {Kari A.} and Laitio, {Timo T.} and Aro, {Hannu T.}",
year = "2014",
month = "12",
day = "1",
doi = "10.1016/j.jmbbm.2014.08.028",
language = "English",
volume = "40",
pages = "190--200",
journal = "Journal of the Mechanical Behavior of Biomedical Materials",
issn = "1751-6161",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Osteointegration of PLGA implants with nanostructured or microsized β-TCP particles in a minipig model

AU - Kulkova, Julia

AU - Moritz, Niko

AU - Suokas, Esa O.

AU - Strandberg, Niko

AU - Leino, Kari A.

AU - Laitio, Timo T.

AU - Aro, Hannu T.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Bioresorbable suture anchors and interference screws have certain benefits over equivalent titanium-alloy implants. However, there is a need for compositional improvement of currently used bioresorbable implants. We hypothesized that implants made of poly(. l-lactide-co-glycolide) (PLGA) compounded with nanostructured particles of beta-tricalcium phosphate (β-TCP) would induce stronger osteointegration than implants made of PLGA compounded with microsized β-TCP particles. The experimental nanostructured self-reinforced PLGA (85L:15G)/β-TCP composite was made by high-energy ball-milling. Self-reinforced microsized PLGA (95L:5G)/β-TCP composite was prepared by melt-compounding. The composites were characterized by gas chromatography, Ubbelohde viscometry, scanning electron microscopy, laser diffractometry, and standard mechanical tests. Four groups of implants were prepared for the controlled laboratory study employing a minipig animal model. Implants in the first two groups were prepared from nanostructured and microsized PLGA/β-TCP composites respectively. Microroughened titanium-alloy (Ti6Al4V) implants served as positive intra-animal control, and pure PLGA implants as negative control. Cone-shaped implants were inserted in a random order unilaterally in the anterior cortex of the femoral shaft. Eight weeks after surgery, the mechanical strength of osteointegration of the implants was measured by a push-out test. The quality of new bone surrounding the implant was assessed by microcomputed tomography and histology. Implants made of nanostructured PLGA/β-TCP composite did not show improved mechanical osteointegration compared with the implants made of microsized PLGA/β-TCP composite. In the intra-animal comparison, the push-out force of two PLGA/β-TCP composites was 35-60% of that obtained with Ti6Al4V implants. The implant materials did not result in distinct differences in quality of new bone surrounding the implant.

AB - Bioresorbable suture anchors and interference screws have certain benefits over equivalent titanium-alloy implants. However, there is a need for compositional improvement of currently used bioresorbable implants. We hypothesized that implants made of poly(. l-lactide-co-glycolide) (PLGA) compounded with nanostructured particles of beta-tricalcium phosphate (β-TCP) would induce stronger osteointegration than implants made of PLGA compounded with microsized β-TCP particles. The experimental nanostructured self-reinforced PLGA (85L:15G)/β-TCP composite was made by high-energy ball-milling. Self-reinforced microsized PLGA (95L:5G)/β-TCP composite was prepared by melt-compounding. The composites were characterized by gas chromatography, Ubbelohde viscometry, scanning electron microscopy, laser diffractometry, and standard mechanical tests. Four groups of implants were prepared for the controlled laboratory study employing a minipig animal model. Implants in the first two groups were prepared from nanostructured and microsized PLGA/β-TCP composites respectively. Microroughened titanium-alloy (Ti6Al4V) implants served as positive intra-animal control, and pure PLGA implants as negative control. Cone-shaped implants were inserted in a random order unilaterally in the anterior cortex of the femoral shaft. Eight weeks after surgery, the mechanical strength of osteointegration of the implants was measured by a push-out test. The quality of new bone surrounding the implant was assessed by microcomputed tomography and histology. Implants made of nanostructured PLGA/β-TCP composite did not show improved mechanical osteointegration compared with the implants made of microsized PLGA/β-TCP composite. In the intra-animal comparison, the push-out force of two PLGA/β-TCP composites was 35-60% of that obtained with Ti6Al4V implants. The implant materials did not result in distinct differences in quality of new bone surrounding the implant.

KW - Beta-tricalcium phosphate

KW - Bioresorbable bone implants

KW - Composite

KW - Minipig

KW - Nanostructure

KW - Poly(l-lactide-co-glycolide)

UR - http://www.scopus.com/inward/record.url?scp=84907564531&partnerID=8YFLogxK

U2 - 10.1016/j.jmbbm.2014.08.028

DO - 10.1016/j.jmbbm.2014.08.028

M3 - Article

VL - 40

SP - 190

EP - 200

JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

SN - 1751-6161

ER -