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Photodynamic therapy in urology: What can we do now and where are we heading?

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Photodynamic therapy in urology : What can we do now and where are we heading? / Bozzini, G.; Colin, P.; Betrouni, N.; Nevoux, P.; Ouzzane, A.; Puech, P.; Villers, A.; Mordon, S.

In: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, Vol. 9, No. 3, 09.2012, p. 261-273.

Research output: Contribution to journalReview ArticleScientificpeer-review

Harvard

Bozzini, G, Colin, P, Betrouni, N, Nevoux, P, Ouzzane, A, Puech, P, Villers, A & Mordon, S 2012, 'Photodynamic therapy in urology: What can we do now and where are we heading?', PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, vol. 9, no. 3, pp. 261-273. https://doi.org/10.1016/j.pdpdt.2012.01.005

APA

Bozzini, G., Colin, P., Betrouni, N., Nevoux, P., Ouzzane, A., Puech, P., ... Mordon, S. (2012). Photodynamic therapy in urology: What can we do now and where are we heading? PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 9(3), 261-273. https://doi.org/10.1016/j.pdpdt.2012.01.005

Vancouver

Bozzini G, Colin P, Betrouni N, Nevoux P, Ouzzane A, Puech P et al. Photodynamic therapy in urology: What can we do now and where are we heading? PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY. 2012 Sep;9(3):261-273. https://doi.org/10.1016/j.pdpdt.2012.01.005

Author

Bozzini, G. ; Colin, P. ; Betrouni, N. ; Nevoux, P. ; Ouzzane, A. ; Puech, P. ; Villers, A. ; Mordon, S. / Photodynamic therapy in urology : What can we do now and where are we heading?. In: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY. 2012 ; Vol. 9, No. 3. pp. 261-273.

Bibtex - Download

@article{6f24e4cdca9e4959b65e480d67bba302,
title = "Photodynamic therapy in urology: What can we do now and where are we heading?",
abstract = "Background: Photodynamic therapy (PDT) is an innovative technique in oncologic urology. Its application appears increasingly realistic to all kind of cancers with technological progress made in treatment planning and light delivery associated with the emergence of novel photosensitizers. The aim of this study is to review applications of this technique in urology. Materials and methods: We reviewed the literature on PDT for urological malignancies with the following key words: photodynamic therapy, prostate cancer, kidney cancer, urothelial cancer, penile cancer and then by cross-referencing from previously identified studies. Results: Focal therapy of prostate cancer is an application of PDT. Clinical studies are ongoing to determine PDT efficacy and safety. PDT as salvage treatment after radiotherapy has been tested. Oncologic results were promising but important side effects were reported. Individual dosimetric planning is necessary to avoid toxicity.PDT was tested to treat superficial bladder carcinoma with promising oncologic results. Serious side effects have limited use of first photosensitizers generation. Second generation of photosensitizer allowed reducing morbidity. For upper urinary tract carcinoma and urethra, data are limited. Few studies described PDT application in penile oncology for conservative management of carcinoma in situ and premalignant lesions. For renal cancer, PDT was only tested on preclinical model despite of its potential application. No data is available concerning PDT application for testicular cancer. Conclusion: PDT clinical applications in urology have proved a kind of efficiency balanced with an important morbidity. Development of new photosensitizer generations and improvement in illumination protocols should permit to decrease side effects.",
keywords = "Kidney cancer, Penile cancer, Photodynamic therapy, Prostate cancer, Testicular cancer, Urothelial cancer",
author = "G. Bozzini and P. Colin and N. Betrouni and P. Nevoux and A. Ouzzane and P. Puech and A. Villers and S. Mordon",
year = "2012",
month = "9",
doi = "10.1016/j.pdpdt.2012.01.005",
language = "English",
volume = "9",
pages = "261--273",
journal = "PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY",
issn = "1572-1000",
publisher = "Elsevier",
number = "3",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Photodynamic therapy in urology

T2 - What can we do now and where are we heading?

AU - Bozzini, G.

AU - Colin, P.

AU - Betrouni, N.

AU - Nevoux, P.

AU - Ouzzane, A.

AU - Puech, P.

AU - Villers, A.

AU - Mordon, S.

PY - 2012/9

Y1 - 2012/9

N2 - Background: Photodynamic therapy (PDT) is an innovative technique in oncologic urology. Its application appears increasingly realistic to all kind of cancers with technological progress made in treatment planning and light delivery associated with the emergence of novel photosensitizers. The aim of this study is to review applications of this technique in urology. Materials and methods: We reviewed the literature on PDT for urological malignancies with the following key words: photodynamic therapy, prostate cancer, kidney cancer, urothelial cancer, penile cancer and then by cross-referencing from previously identified studies. Results: Focal therapy of prostate cancer is an application of PDT. Clinical studies are ongoing to determine PDT efficacy and safety. PDT as salvage treatment after radiotherapy has been tested. Oncologic results were promising but important side effects were reported. Individual dosimetric planning is necessary to avoid toxicity.PDT was tested to treat superficial bladder carcinoma with promising oncologic results. Serious side effects have limited use of first photosensitizers generation. Second generation of photosensitizer allowed reducing morbidity. For upper urinary tract carcinoma and urethra, data are limited. Few studies described PDT application in penile oncology for conservative management of carcinoma in situ and premalignant lesions. For renal cancer, PDT was only tested on preclinical model despite of its potential application. No data is available concerning PDT application for testicular cancer. Conclusion: PDT clinical applications in urology have proved a kind of efficiency balanced with an important morbidity. Development of new photosensitizer generations and improvement in illumination protocols should permit to decrease side effects.

AB - Background: Photodynamic therapy (PDT) is an innovative technique in oncologic urology. Its application appears increasingly realistic to all kind of cancers with technological progress made in treatment planning and light delivery associated with the emergence of novel photosensitizers. The aim of this study is to review applications of this technique in urology. Materials and methods: We reviewed the literature on PDT for urological malignancies with the following key words: photodynamic therapy, prostate cancer, kidney cancer, urothelial cancer, penile cancer and then by cross-referencing from previously identified studies. Results: Focal therapy of prostate cancer is an application of PDT. Clinical studies are ongoing to determine PDT efficacy and safety. PDT as salvage treatment after radiotherapy has been tested. Oncologic results were promising but important side effects were reported. Individual dosimetric planning is necessary to avoid toxicity.PDT was tested to treat superficial bladder carcinoma with promising oncologic results. Serious side effects have limited use of first photosensitizers generation. Second generation of photosensitizer allowed reducing morbidity. For upper urinary tract carcinoma and urethra, data are limited. Few studies described PDT application in penile oncology for conservative management of carcinoma in situ and premalignant lesions. For renal cancer, PDT was only tested on preclinical model despite of its potential application. No data is available concerning PDT application for testicular cancer. Conclusion: PDT clinical applications in urology have proved a kind of efficiency balanced with an important morbidity. Development of new photosensitizer generations and improvement in illumination protocols should permit to decrease side effects.

KW - Kidney cancer

KW - Penile cancer

KW - Photodynamic therapy

KW - Prostate cancer

KW - Testicular cancer

KW - Urothelial cancer

UR - http://www.scopus.com/inward/record.url?scp=84865987335&partnerID=8YFLogxK

U2 - 10.1016/j.pdpdt.2012.01.005

DO - 10.1016/j.pdpdt.2012.01.005

M3 - Review Article

VL - 9

SP - 261

EP - 273

JO - PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY

JF - PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY

SN - 1572-1000

IS - 3

ER -