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PIP2 and Talin Join Forces to Activate Integrin

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Details

Original languageEnglish
Pages (from-to)12381-12389
Number of pages9
JournalJournal of Physical Chemistry Part B
Volume119
Issue number38
Early online date26 Aug 2015
DOIs
Publication statusPublished - 24 Sep 2015
Publication typeA1 Journal article-refereed

Abstract

Integrins are major players in cell adhesion and migration, and malfunctions in controlling their activity are associated with various diseases. Nevertheless, the details of integrin activation are not completely understood, and the role of lipids in the process is largely unknown. Herein, we show using atomistic molecular dynamics simulations that the interplay of phosphatidylinositol 4,5-bisphosphate (PIP2) and talin may directly alter the conformation of integrin αIIbβ3. Our results provide a new perspective on the role of PIP2 in integrin activation and indicate that the charged PIP2 lipid headgroup can perturb a clasp at the cytoplasmic face of the integrin heterodimer.

Publication forum classification

Field of science, Statistics Finland