PIP2 and Talin Join Forces to Activate Integrin
Research output: Contribution to journal › Article › Scientific › peer-review
|Number of pages||9|
|Journal||Journal of Physical Chemistry Part B|
|Early online date||26 Aug 2015|
|Publication status||Published - 24 Sep 2015|
|Publication type||A1 Journal article-refereed|
Integrins are major players in cell adhesion and migration, and malfunctions in controlling their activity are associated with various diseases. Nevertheless, the details of integrin activation are not completely understood, and the role of lipids in the process is largely unknown. Herein, we show using atomistic molecular dynamics simulations that the interplay of phosphatidylinositol 4,5-bisphosphate (PIP2) and talin may directly alter the conformation of integrin αIIbβ3. Our results provide a new perspective on the role of PIP2 in integrin activation and indicate that the charged PIP2 lipid headgroup can perturb a clasp at the cytoplasmic face of the integrin heterodimer.