Preparation of 5-substituted 2-carboxyindoles on solid support
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Details
| Original language | English |
|---|---|
| Pages (from-to) | 2443-2446 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 41 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 1 Apr 2000 |
| Externally published | Yes |
| Publication type | A1 Journal article-refereed |
Abstract
The preparation of 5-substituted 2-carboxyindoles on solid support is reported. In the approach, the indole moiety is synthesized in solution phase, followed by nitro-group reduction, reductive amination and alkylation on solid support. The method provides a simple and convenient route for the preparation of 5-substituted 2-carboxyindoles with high purity and good yield. (C) 2000 Elsevier Science Ltd.