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Preparation of 5-substituted 2-carboxyindoles on solid support

Research output: Contribution to journalArticleScientificpeer-review


Original languageEnglish
Pages (from-to)2443-2446
Number of pages4
JournalTetrahedron Letters
Issue number14
Publication statusPublished - 1 Apr 2000
Externally publishedYes
Publication typeA1 Journal article-refereed


The preparation of 5-substituted 2-carboxyindoles on solid support is reported. In the approach, the indole moiety is synthesized in solution phase, followed by nitro-group reduction, reductive amination and alkylation on solid support. The method provides a simple and convenient route for the preparation of 5-substituted 2-carboxyindoles with high purity and good yield. (C) 2000 Elsevier Science Ltd.