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Printable and flexible macroporous organosilica film with high protein adsorption capacity

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)1934-1937
Number of pages4
JournalThin Solid Films
Volume520
Issue number6
DOIs
Publication statusPublished - 1 Jan 2012
Publication typeA1 Journal article-refereed

Abstract

An approach for creating a flexible and macroporous silsesquioxane film using phase separation method is described. The porous film was prepared by a simple coating method where sol-gel solution containing polyacrylic acid (PAA) and 1,6-bis(trimethoxysilyl)hexane in water was applied on boehmite silica coated polymethylmethacrylate (PMMA) film. After drying, the water soluble PAA template was removed by washing the film with water revealing the porous film. With certain ratios of PAA and water, fully co-continuous pore system with open surface was obtained. Porous films with 3-4 μm thickness were found to be highly flexible. The biocompatibility of the porous film was tested by immobilizing a high affinity biotin-binding chimeric avidin (ChiAVD(I117Y)) into the porous matrix The porous film was found to adsorb higher amounts of functional chimeric avidin compared to the pure PMMA film or a boehmite silica coated PMMA film.

Keywords

  • Flexible coatings, Phase separation, Porous films, Printable coatings, Protein immobilization, Sol-gel