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Prospective ex-vivo study on thermal effects in human skin phototypes II, IV and VI: A comparison between the 808, 1064, 1210 and 1320-nm diode laser

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Prospective ex-vivo study on thermal effects in human skin phototypes II, IV and VI : A comparison between the 808, 1064, 1210 and 1320-nm diode laser. / Leclère, Franck Marie P; Magalon, Guy; Philandrianos, Cécile; Unglaub, Frank; Servell, Pascal; Mordon, Serge.

In: JOURNAL OF COSMETIC AND LASER THERAPY, Vol. 14, No. 1, 02.2012, p. 7-13.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Leclère, FMP, Magalon, G, Philandrianos, C, Unglaub, F, Servell, P & Mordon, S 2012, 'Prospective ex-vivo study on thermal effects in human skin phototypes II, IV and VI: A comparison between the 808, 1064, 1210 and 1320-nm diode laser', JOURNAL OF COSMETIC AND LASER THERAPY, vol. 14, no. 1, pp. 7-13. https://doi.org/10.3109/14764172.2011.634419

APA

Leclère, F. M. P., Magalon, G., Philandrianos, C., Unglaub, F., Servell, P., & Mordon, S. (2012). Prospective ex-vivo study on thermal effects in human skin phototypes II, IV and VI: A comparison between the 808, 1064, 1210 and 1320-nm diode laser. JOURNAL OF COSMETIC AND LASER THERAPY, 14(1), 7-13. https://doi.org/10.3109/14764172.2011.634419

Vancouver

Leclère FMP, Magalon G, Philandrianos C, Unglaub F, Servell P, Mordon S. Prospective ex-vivo study on thermal effects in human skin phototypes II, IV and VI: A comparison between the 808, 1064, 1210 and 1320-nm diode laser. JOURNAL OF COSMETIC AND LASER THERAPY. 2012 Feb;14(1):7-13. https://doi.org/10.3109/14764172.2011.634419

Author

Leclère, Franck Marie P ; Magalon, Guy ; Philandrianos, Cécile ; Unglaub, Frank ; Servell, Pascal ; Mordon, Serge. / Prospective ex-vivo study on thermal effects in human skin phototypes II, IV and VI : A comparison between the 808, 1064, 1210 and 1320-nm diode laser. In: JOURNAL OF COSMETIC AND LASER THERAPY. 2012 ; Vol. 14, No. 1. pp. 7-13.

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@article{3d0d83fefee34cf685bec7957a783a36,
title = "Prospective ex-vivo study on thermal effects in human skin phototypes II, IV and VI: A comparison between the 808, 1064, 1210 and 1320-nm diode laser",
abstract = "Background: Laser Assisted Skin Healing (LASH) was first introduced in 2001 by Capon and Mordon to prevent keloids and hypertrophic scars. LASH requires homogenous heating throughout the full thickness of the skin around the wound. However, LASH therapy with 808-nm diode laser is deemed to be only applicable for phototype IIV due to melanin absorption. This prospective ex-vivo study aims to evaluate the thermal effects of different wavelengths (808, 1064, 1210 and 1320 nm) on human skin phototype II, IV and VI. Material and methods: Laser shots were applied on skin explants phototypes II, IV and VI. The following laser settings were used: 808, 1064, 1210 and 1320-nm diode laser, Spot size 20 × 3.7 mm, Power 3 W, Irradiance 4 W/cm, 50 shots for each phototype and wavelength. The surface temperature at 2 and 4-mm depth respectively was evaluated by an infrared camera and a low inertia micro thermocouple. Results: For the 1064, 1210 and 1320-nm wavelengths, the temperature gradient between the surface and 2-mm depth after an irradiation time of 15 s was less than 4.0°C for each phototype. For the 808 nm, the gradient was 0.8°C and 4.4°C in phototype II and IV respectively, but reached 17.2°C in phototype VI. Strong absorption by melanin of skin phototype VI induced unwanted temperature increases at the dermis-epidermis junction, making this wavelength unsuitable for LASH therapy for this phototype. Among the three other wavelengths, the discussion section indicates strong blood absorption at 1064 nm and presents both 1210 and 1320 nm as excellent compromises for LASH therapy across the whole range of phototypes. Conclusion: Being poorly absorbed by melanin, both 1210 and 1320-nm wavelengths ensure homogeneity of temperature throughout the full skin explant thickness. Their possible utilization for efficient LASH therapy should now be confirmed by prospective in vivo studies.",
keywords = "Cicatrisation, Diode laser, Keloids, Laser, Lash, Melanin, Phototypes, Skin",
author = "Lecl{\`e}re, {Franck Marie P} and Guy Magalon and C{\'e}cile Philandrianos and Frank Unglaub and Pascal Servell and Serge Mordon",
year = "2012",
month = "2",
doi = "10.3109/14764172.2011.634419",
language = "English",
volume = "14",
pages = "7--13",
journal = "JOURNAL OF COSMETIC AND LASER THERAPY",
issn = "1476-4172",
publisher = "Informa Healthcare",
number = "1",

}

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TY - JOUR

T1 - Prospective ex-vivo study on thermal effects in human skin phototypes II, IV and VI

T2 - A comparison between the 808, 1064, 1210 and 1320-nm diode laser

AU - Leclère, Franck Marie P

AU - Magalon, Guy

AU - Philandrianos, Cécile

AU - Unglaub, Frank

AU - Servell, Pascal

AU - Mordon, Serge

PY - 2012/2

Y1 - 2012/2

N2 - Background: Laser Assisted Skin Healing (LASH) was first introduced in 2001 by Capon and Mordon to prevent keloids and hypertrophic scars. LASH requires homogenous heating throughout the full thickness of the skin around the wound. However, LASH therapy with 808-nm diode laser is deemed to be only applicable for phototype IIV due to melanin absorption. This prospective ex-vivo study aims to evaluate the thermal effects of different wavelengths (808, 1064, 1210 and 1320 nm) on human skin phototype II, IV and VI. Material and methods: Laser shots were applied on skin explants phototypes II, IV and VI. The following laser settings were used: 808, 1064, 1210 and 1320-nm diode laser, Spot size 20 × 3.7 mm, Power 3 W, Irradiance 4 W/cm, 50 shots for each phototype and wavelength. The surface temperature at 2 and 4-mm depth respectively was evaluated by an infrared camera and a low inertia micro thermocouple. Results: For the 1064, 1210 and 1320-nm wavelengths, the temperature gradient between the surface and 2-mm depth after an irradiation time of 15 s was less than 4.0°C for each phototype. For the 808 nm, the gradient was 0.8°C and 4.4°C in phototype II and IV respectively, but reached 17.2°C in phototype VI. Strong absorption by melanin of skin phototype VI induced unwanted temperature increases at the dermis-epidermis junction, making this wavelength unsuitable for LASH therapy for this phototype. Among the three other wavelengths, the discussion section indicates strong blood absorption at 1064 nm and presents both 1210 and 1320 nm as excellent compromises for LASH therapy across the whole range of phototypes. Conclusion: Being poorly absorbed by melanin, both 1210 and 1320-nm wavelengths ensure homogeneity of temperature throughout the full skin explant thickness. Their possible utilization for efficient LASH therapy should now be confirmed by prospective in vivo studies.

AB - Background: Laser Assisted Skin Healing (LASH) was first introduced in 2001 by Capon and Mordon to prevent keloids and hypertrophic scars. LASH requires homogenous heating throughout the full thickness of the skin around the wound. However, LASH therapy with 808-nm diode laser is deemed to be only applicable for phototype IIV due to melanin absorption. This prospective ex-vivo study aims to evaluate the thermal effects of different wavelengths (808, 1064, 1210 and 1320 nm) on human skin phototype II, IV and VI. Material and methods: Laser shots were applied on skin explants phototypes II, IV and VI. The following laser settings were used: 808, 1064, 1210 and 1320-nm diode laser, Spot size 20 × 3.7 mm, Power 3 W, Irradiance 4 W/cm, 50 shots for each phototype and wavelength. The surface temperature at 2 and 4-mm depth respectively was evaluated by an infrared camera and a low inertia micro thermocouple. Results: For the 1064, 1210 and 1320-nm wavelengths, the temperature gradient between the surface and 2-mm depth after an irradiation time of 15 s was less than 4.0°C for each phototype. For the 808 nm, the gradient was 0.8°C and 4.4°C in phototype II and IV respectively, but reached 17.2°C in phototype VI. Strong absorption by melanin of skin phototype VI induced unwanted temperature increases at the dermis-epidermis junction, making this wavelength unsuitable for LASH therapy for this phototype. Among the three other wavelengths, the discussion section indicates strong blood absorption at 1064 nm and presents both 1210 and 1320 nm as excellent compromises for LASH therapy across the whole range of phototypes. Conclusion: Being poorly absorbed by melanin, both 1210 and 1320-nm wavelengths ensure homogeneity of temperature throughout the full skin explant thickness. Their possible utilization for efficient LASH therapy should now be confirmed by prospective in vivo studies.

KW - Cicatrisation

KW - Diode laser

KW - Keloids

KW - Laser

KW - Lash

KW - Melanin

KW - Phototypes

KW - Skin

UR - http://www.scopus.com/inward/record.url?scp=84856596374&partnerID=8YFLogxK

U2 - 10.3109/14764172.2011.634419

DO - 10.3109/14764172.2011.634419

M3 - Article

VL - 14

SP - 7

EP - 13

JO - JOURNAL OF COSMETIC AND LASER THERAPY

JF - JOURNAL OF COSMETIC AND LASER THERAPY

SN - 1476-4172

IS - 1

ER -