Reduction of Limited Angle Artifacts in Medical Tomography via Image Reconstruction
Research output: Book/Report › Doctoral thesis › Collection of Articles
|Number of pages||62|
|Publication status||Published - 8 Feb 2019|
|Publication type||G5 Doctoral dissertation (article)|
|Name||Tampere University Dissertations|
Development of reconstruction methods is an incremental process starting with testing on simple phantoms towards more clinically relevant ones by modeling the respective physical processes involved. In this work, phantoms were constructed to ensure that the proposed reconstruction methods addressed to the limited angle problem. The reconstructed images were assessed qualitatively and quantitatively in terms of noise reduction, edge sharpness and contrast recovery.
Maximum a posteriori (MAP) estimation with median root prior (MRP) was selected for the reconstruction of limited angle measurements. MAP with MRP successfully reduced the artifacts caused by limited angle data in various datasets, tested with the reconstruction of both list-mode and projection data. In all cases, its performance was found to be superior to conventional reconstruction methods such as total-variation (TV) prior, maximum likelihood expectation maximization (MLEM) and ﬁltered backprojection (FBP). MAP with MRP was also more robust with respect to parameter selection than MAP with TV prior.
This thesis demonstrates the wide-range applicability of MAP with MRP in medical tomography, especially in low-dose imaging. Furthermore, we emphasize the importance of developing and testing reconstruction methods with application-speciﬁc phantoms, together with the properties and limitations of the measurements in mind.