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Reflux symptoms and side effects among patients with gastroesophageal reflux disease at baseline, during treatment with PPIs, and after nissen fundoplication

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Reflux symptoms and side effects among patients with gastroesophageal reflux disease at baseline, during treatment with PPIs, and after nissen fundoplication. / Rantanen, Tuomo; Kiljander, Toni; Salminen, Paulina; Ranta, Arto; Oksala, Niku; Kellokumpu, Ilmo.

In: WORLD JOURNAL OF SURGERY, Vol. 37, No. 6, 06.2013, p. 1291-1296.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Rantanen, T, Kiljander, T, Salminen, P, Ranta, A, Oksala, N & Kellokumpu, I 2013, 'Reflux symptoms and side effects among patients with gastroesophageal reflux disease at baseline, during treatment with PPIs, and after nissen fundoplication', WORLD JOURNAL OF SURGERY, vol. 37, no. 6, pp. 1291-1296. https://doi.org/10.1007/s00268-013-1979-8

APA

Rantanen, T., Kiljander, T., Salminen, P., Ranta, A., Oksala, N., & Kellokumpu, I. (2013). Reflux symptoms and side effects among patients with gastroesophageal reflux disease at baseline, during treatment with PPIs, and after nissen fundoplication. WORLD JOURNAL OF SURGERY, 37(6), 1291-1296. https://doi.org/10.1007/s00268-013-1979-8

Vancouver

Author

Rantanen, Tuomo ; Kiljander, Toni ; Salminen, Paulina ; Ranta, Arto ; Oksala, Niku ; Kellokumpu, Ilmo. / Reflux symptoms and side effects among patients with gastroesophageal reflux disease at baseline, during treatment with PPIs, and after nissen fundoplication. In: WORLD JOURNAL OF SURGERY. 2013 ; Vol. 37, No. 6. pp. 1291-1296.

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@article{98735c74597f4d31a3f01d68331cd1ed,
title = "Reflux symptoms and side effects among patients with gastroesophageal reflux disease at baseline, during treatment with PPIs, and after nissen fundoplication",
abstract = "Background: There are no prospective studies available on the behavior of extraesophageal and esophageal symptoms and treatment-related side effects in patients without effective antireflux medication, receiving the most effective antireflux medication, and after laparoscopic fundoplication. Methods: Extraesophageal and esophageal reflux symptoms and treatment-related side effects were assessed in 60 patients while they were on no effective antireflux medication (three-week washout period), after three month of treatment with double-dose esomeprazole, and 3 months after laparoscopic Nissen fundoplication. Esophageal and extraesophageal reflux symptoms, rectal flatulence, and bloating were analyzed with the visual analog scale. In addition, dysphagia, rectal flatulence, and bloating were recorded as none, mild, moderate, or severe. Results: Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were further reduced after fundoplication. Dysphagia and flatulence did not increase from baseline after surgery. Bloating decreased both after treatment with esomeprazole and after fundoplication. In contrast, dysphagia and increased flatus were found more often after surgery than during treatment with esomeprazole. Dysphagia and rectal flatulence were less common during treatment with esomeprazole than at baseline or after surgery. Conclusions: Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were reduced further after fundoplication. Any treatment-related side effect was not increased after surgery when compared to baseline. However, compared to esomeprazole there was more dysphagia and flatulence after fundoplication.",
author = "Tuomo Rantanen and Toni Kiljander and Paulina Salminen and Arto Ranta and Niku Oksala and Ilmo Kellokumpu",
year = "2013",
month = "6",
doi = "10.1007/s00268-013-1979-8",
language = "English",
volume = "37",
pages = "1291--1296",
journal = "WORLD JOURNAL OF SURGERY",
issn = "0364-2313",
publisher = "Springer Verlag",
number = "6",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Reflux symptoms and side effects among patients with gastroesophageal reflux disease at baseline, during treatment with PPIs, and after nissen fundoplication

AU - Rantanen, Tuomo

AU - Kiljander, Toni

AU - Salminen, Paulina

AU - Ranta, Arto

AU - Oksala, Niku

AU - Kellokumpu, Ilmo

PY - 2013/6

Y1 - 2013/6

N2 - Background: There are no prospective studies available on the behavior of extraesophageal and esophageal symptoms and treatment-related side effects in patients without effective antireflux medication, receiving the most effective antireflux medication, and after laparoscopic fundoplication. Methods: Extraesophageal and esophageal reflux symptoms and treatment-related side effects were assessed in 60 patients while they were on no effective antireflux medication (three-week washout period), after three month of treatment with double-dose esomeprazole, and 3 months after laparoscopic Nissen fundoplication. Esophageal and extraesophageal reflux symptoms, rectal flatulence, and bloating were analyzed with the visual analog scale. In addition, dysphagia, rectal flatulence, and bloating were recorded as none, mild, moderate, or severe. Results: Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were further reduced after fundoplication. Dysphagia and flatulence did not increase from baseline after surgery. Bloating decreased both after treatment with esomeprazole and after fundoplication. In contrast, dysphagia and increased flatus were found more often after surgery than during treatment with esomeprazole. Dysphagia and rectal flatulence were less common during treatment with esomeprazole than at baseline or after surgery. Conclusions: Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were reduced further after fundoplication. Any treatment-related side effect was not increased after surgery when compared to baseline. However, compared to esomeprazole there was more dysphagia and flatulence after fundoplication.

AB - Background: There are no prospective studies available on the behavior of extraesophageal and esophageal symptoms and treatment-related side effects in patients without effective antireflux medication, receiving the most effective antireflux medication, and after laparoscopic fundoplication. Methods: Extraesophageal and esophageal reflux symptoms and treatment-related side effects were assessed in 60 patients while they were on no effective antireflux medication (three-week washout period), after three month of treatment with double-dose esomeprazole, and 3 months after laparoscopic Nissen fundoplication. Esophageal and extraesophageal reflux symptoms, rectal flatulence, and bloating were analyzed with the visual analog scale. In addition, dysphagia, rectal flatulence, and bloating were recorded as none, mild, moderate, or severe. Results: Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were further reduced after fundoplication. Dysphagia and flatulence did not increase from baseline after surgery. Bloating decreased both after treatment with esomeprazole and after fundoplication. In contrast, dysphagia and increased flatus were found more often after surgery than during treatment with esomeprazole. Dysphagia and rectal flatulence were less common during treatment with esomeprazole than at baseline or after surgery. Conclusions: Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were reduced further after fundoplication. Any treatment-related side effect was not increased after surgery when compared to baseline. However, compared to esomeprazole there was more dysphagia and flatulence after fundoplication.

UR - http://www.scopus.com/inward/record.url?scp=84877732649&partnerID=8YFLogxK

U2 - 10.1007/s00268-013-1979-8

DO - 10.1007/s00268-013-1979-8

M3 - Article

VL - 37

SP - 1291

EP - 1296

JO - WORLD JOURNAL OF SURGERY

JF - WORLD JOURNAL OF SURGERY

SN - 0364-2313

IS - 6

ER -