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Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes

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Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes. / Kim, Jiyeong; Kuusela, Jukka; Aalto-Setälä, Katriina; Räsänen, Esa.

Computing in Cardiology 2017. Vol. 44 2017. (Computing in Cardiology).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

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Kim, J, Kuusela, J, Aalto-Setälä, K & Räsänen, E 2017, Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes. in Computing in Cardiology 2017. vol. 44, Computing in Cardiology, Computing in cardiology conference, 1/01/00. https://doi.org/10.22489/CinC.2017.207-155

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Kim, Jiyeong ; Kuusela, Jukka ; Aalto-Setälä, Katriina ; Räsänen, Esa. / Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes. Computing in Cardiology 2017. Vol. 44 2017. (Computing in Cardiology).

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@inproceedings{1c3bfbbc2ca24e4789e50dd622ec7de2,
title = "Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes",
abstract = "A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.",
author = "Jiyeong Kim and Jukka Kuusela and Katriina Aalto-Set{\"a}l{\"a} and Esa R{\"a}s{\"a}nen",
note = "DUPL=42741204",
year = "2017",
doi = "10.22489/CinC.2017.207-155",
language = "English",
volume = "44",
series = "Computing in Cardiology",
booktitle = "Computing in Cardiology 2017",

}

RIS (suitable for import to EndNote) - Download

TY - GEN

T1 - Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes

AU - Kim, Jiyeong

AU - Kuusela, Jukka

AU - Aalto-Setälä, Katriina

AU - Räsänen, Esa

N1 - DUPL=42741204

PY - 2017

Y1 - 2017

N2 - A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.

AB - A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.

U2 - 10.22489/CinC.2017.207-155

DO - 10.22489/CinC.2017.207-155

M3 - Conference contribution

VL - 44

T3 - Computing in Cardiology

BT - Computing in Cardiology 2017

ER -