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SiMEA: a Framework for simulating neurons on Multi-Electrode Array

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Details

Original languageEnglish
Title of host publicationProceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PublisherIEEE
Number of pages4
ISBN (Electronic)978-1-4577-0220-4
DOIs
Publication statusPublished - 20 Aug 2016
Publication typeA4 Article in a conference publication
EventAnnual International Conference of the IEEE Engineering in Medicine and Biology Society -
Duration: 1 Jan 1900 → …

Publication series

Name
ISSN (Electronic)1558-4615

Conference

ConferenceAnnual International Conference of the IEEE Engineering in Medicine and Biology Society
Period1/01/00 → …

Abstract

A Multi-Electrode Array (MEA) is a practical device for recording the extracellular activity of in-vitro biological culture. Such culture - for instance neurons - is prone to mistakes leading to irrelevant recordings or no recording at all. Additionally, with the expenses generated by in-vitro culture, minimizing risks is a must. This paper proposes a framework designed and implemented for simulating the spatial positioning of neuronal cultures on a MEA. The framework serves as a sandbox for researchers to simulate the model of their MEA experiments before its eventual in-vitro implementation. The framework enables simulating the density of the plated culture, the death of cells over time, choosing diverse reconstructed morphologies of cells, and simulating their spiking activity in interaction with Brian2 simulator.

Publication forum classification

Field of science, Statistics Finland