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Sol-gel synthesis of quaternary (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x bioresorbable glasses for bone tissue engineering applications (x = 0, 5, 10, or 15)

Research output: Contribution to journalArticleScientificpeer-review

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Sol-gel synthesis of quaternary (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x bioresorbable glasses for bone tissue engineering applications (x = 0, 5, 10, or 15). / Foroutan, Farzad; Walters, Nick J.; Owens, Gareth J.; Mordan, Nicola J.; Kim, Hae Won; de Leeuw, Nora H.; Knowles, Jonathan C.

In: Biomedical materials (Bristol, England), Vol. 10, No. 4, 01.08.2015, p. 45025.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Foroutan, F, Walters, NJ, Owens, GJ, Mordan, NJ, Kim, HW, de Leeuw, NH & Knowles, JC 2015, 'Sol-gel synthesis of quaternary (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x bioresorbable glasses for bone tissue engineering applications (x = 0, 5, 10, or 15)', Biomedical materials (Bristol, England), vol. 10, no. 4, pp. 45025. https://doi.org/10.1088/1748-6041/10/4/045025

APA

Foroutan, F., Walters, N. J., Owens, G. J., Mordan, N. J., Kim, H. W., de Leeuw, N. H., & Knowles, J. C. (2015). Sol-gel synthesis of quaternary (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x bioresorbable glasses for bone tissue engineering applications (x = 0, 5, 10, or 15). Biomedical materials (Bristol, England), 10(4), 45025. https://doi.org/10.1088/1748-6041/10/4/045025

Vancouver

Foroutan F, Walters NJ, Owens GJ, Mordan NJ, Kim HW, de Leeuw NH et al. Sol-gel synthesis of quaternary (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x bioresorbable glasses for bone tissue engineering applications (x = 0, 5, 10, or 15). Biomedical materials (Bristol, England). 2015 Aug 1;10(4):45025. https://doi.org/10.1088/1748-6041/10/4/045025

Author

Foroutan, Farzad ; Walters, Nick J. ; Owens, Gareth J. ; Mordan, Nicola J. ; Kim, Hae Won ; de Leeuw, Nora H. ; Knowles, Jonathan C. / Sol-gel synthesis of quaternary (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x bioresorbable glasses for bone tissue engineering applications (x = 0, 5, 10, or 15). In: Biomedical materials (Bristol, England). 2015 ; Vol. 10, No. 4. pp. 45025.

Bibtex - Download

@article{4804f338b73944018ae53b141a2e76d6,
title = "Sol-gel synthesis of quaternary (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x bioresorbable glasses for bone tissue engineering applications (x = 0, 5, 10, or 15)",
abstract = "In the present study, we report a new and facile sol-gel synthesis of phosphate-based glasses with the general formula of (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x , where x = 0, 5, 10 or 15, for bone tissue engineering applications. The sol-gel synthesis method allows greater control over glass morphology at relatively low processing temperature (200 °C) in comparison with phosphate-based melt-derived glasses (~1000 °C). The glasses were analyzed using several characterization techniques, including x-ray diffraction (XRD), (31)P magic angle spinning nuclear magnetic resonance ((31)P MAS-NMR), Fourier transform infrared (FTIR) spectroscopy and energy-dispersive x-ray (EDX) spectroscopy, which confirmed the amorphous and glassy nature of the prepared samples. Degradation was assessed by measuring the ion release and pH change of the storage medium. Cytocompatibility was also confirmed by culturing osteoblast-like osteosarcoma cell line MG-63 on the glass microparticles over a seven-day period. Cell attachment to the particles was imaged using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The results revealed the potential of phosphate-based sol-gel derived glasses containing 5 or 10 mol{\%} TiO2, with high surface area, ideal dissolution rate for cell attachment and easily metabolized dissolution products, for bone tissue engineering applications.",
author = "Farzad Foroutan and Walters, {Nick J.} and Owens, {Gareth J.} and Mordan, {Nicola J.} and Kim, {Hae Won} and {de Leeuw}, {Nora H.} and Knowles, {Jonathan C.}",
year = "2015",
month = "8",
day = "1",
doi = "10.1088/1748-6041/10/4/045025",
language = "English",
volume = "10",
pages = "45025",
journal = "Biomedical materials (Bristol, England)",
issn = "1748-605X",
publisher = "IOP Publishing",
number = "4",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Sol-gel synthesis of quaternary (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x bioresorbable glasses for bone tissue engineering applications (x = 0, 5, 10, or 15)

AU - Foroutan, Farzad

AU - Walters, Nick J.

AU - Owens, Gareth J.

AU - Mordan, Nicola J.

AU - Kim, Hae Won

AU - de Leeuw, Nora H.

AU - Knowles, Jonathan C.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - In the present study, we report a new and facile sol-gel synthesis of phosphate-based glasses with the general formula of (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x , where x = 0, 5, 10 or 15, for bone tissue engineering applications. The sol-gel synthesis method allows greater control over glass morphology at relatively low processing temperature (200 °C) in comparison with phosphate-based melt-derived glasses (~1000 °C). The glasses were analyzed using several characterization techniques, including x-ray diffraction (XRD), (31)P magic angle spinning nuclear magnetic resonance ((31)P MAS-NMR), Fourier transform infrared (FTIR) spectroscopy and energy-dispersive x-ray (EDX) spectroscopy, which confirmed the amorphous and glassy nature of the prepared samples. Degradation was assessed by measuring the ion release and pH change of the storage medium. Cytocompatibility was also confirmed by culturing osteoblast-like osteosarcoma cell line MG-63 on the glass microparticles over a seven-day period. Cell attachment to the particles was imaged using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The results revealed the potential of phosphate-based sol-gel derived glasses containing 5 or 10 mol% TiO2, with high surface area, ideal dissolution rate for cell attachment and easily metabolized dissolution products, for bone tissue engineering applications.

AB - In the present study, we report a new and facile sol-gel synthesis of phosphate-based glasses with the general formula of (P2O5)55-(CaO)25-(Na2O)(20-x)-(TiO2) x , where x = 0, 5, 10 or 15, for bone tissue engineering applications. The sol-gel synthesis method allows greater control over glass morphology at relatively low processing temperature (200 °C) in comparison with phosphate-based melt-derived glasses (~1000 °C). The glasses were analyzed using several characterization techniques, including x-ray diffraction (XRD), (31)P magic angle spinning nuclear magnetic resonance ((31)P MAS-NMR), Fourier transform infrared (FTIR) spectroscopy and energy-dispersive x-ray (EDX) spectroscopy, which confirmed the amorphous and glassy nature of the prepared samples. Degradation was assessed by measuring the ion release and pH change of the storage medium. Cytocompatibility was also confirmed by culturing osteoblast-like osteosarcoma cell line MG-63 on the glass microparticles over a seven-day period. Cell attachment to the particles was imaged using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The results revealed the potential of phosphate-based sol-gel derived glasses containing 5 or 10 mol% TiO2, with high surface area, ideal dissolution rate for cell attachment and easily metabolized dissolution products, for bone tissue engineering applications.

UR - http://www.scopus.com/inward/record.url?scp=84983628356&partnerID=8YFLogxK

U2 - 10.1088/1748-6041/10/4/045025

DO - 10.1088/1748-6041/10/4/045025

M3 - Article

VL - 10

SP - 45025

JO - Biomedical materials (Bristol, England)

JF - Biomedical materials (Bristol, England)

SN - 1748-605X

IS - 4

ER -