Solid-phase bromination and Suzuki coupling of 2-carboxyindoles
Research output: Contribution to journal › Article › Scientific › peer-review
|Number of pages||4|
|Journal||Combinatorial Chemistry and High Throughput Screening|
|Publication status||Published - 2001|
|Publication type||A1 Journal article-refereed|
As part of an ongoing lead discovery project we have developed a convenient method for the modification and substitution of indole moieties at the 3-position. Selective bromination of three different 2-carboxyindoles was followed by Suzuki cross-coupling with aryl and heteroaryl boronic acids on a Merrifield resin solid-phase. After column chromatography, yields of the 3- substituted indoles ranged from 42-98%.