Tampere University of Technology

TUTCRIS Research Portal

Solid-phase bromination and Suzuki coupling of 2-carboxyindoles

Research output: Contribution to journalArticleScientificpeer-review


Original languageEnglish
Pages (from-to)521-524
Number of pages4
JournalCombinatorial Chemistry and High Throughput Screening
Issue number6
Publication statusPublished - 2001
Externally publishedYes
Publication typeA1 Journal article-refereed


As part of an ongoing lead discovery project we have developed a convenient method for the modification and substitution of indole moieties at the 3-position. Selective bromination of three different 2-carboxyindoles was followed by Suzuki cross-coupling with aryl and heteroaryl boronic acids on a Merrifield resin solid-phase. After column chromatography, yields of the 3- substituted indoles ranged from 42-98%.