Spatiotemporal Power of Positron Emission Tomography: Pushing the Limits of Poisson Statistics in High-Resolution Human Neurotransmission Studies
Research output: Book/Report › Doctoral thesis › Collection of Articles
|Publisher||Tampere University of Technology|
|Number of pages||101|
|Publication status||Published - 19 Aug 2016|
|Publication type||G5 Doctoral dissertation (article)|
|Name||Tampere University of Technology. Publication|
Main obstacles limiting temporal characterization stem fromthe poor signal-to-noise-ratio of the PET measurement. Inparticular, the limitations related to image reconstruction algorithms and in turn the beneﬁts obtained through regionalanalysis were in the focus of the investigations in this work. Themain ﬁnding was that the best temporal resolution achieved using a commonly recommended iterative reconstruction methodwas insuﬃcient for temporal characterization, while a newlydeveloped algorithm allowing analytical reconstruction showedbetter temporal resolution without decreasing signal-to-noiseratio. Furthermore, a novel atlas-based regional analysis methodwas found superior to the currently employed manual region-ofinterest deﬁnition.
The ﬁndings made through this work will directly assist theplanning of future neurotransmission studies, and it is wishedthat the observations in this work would spark new, more widespread interest on the application of nt-PET in e.g. cognitivestimulation studies.