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Spinal cord injury induces widespread chronic changes in cerebral white matter

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Spinal cord injury induces widespread chronic changes in cerebral white matter. / Ilvesmäki, Tero; Koskinen, Eerika; Brander, Antti; Luoto, Teemu; Öhman, Juha; Eskola, Hannu.

In: Human Brain Mapping, Vol. 38, No. 7, 2017, p. 3637-3647.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Ilvesmäki, T, Koskinen, E, Brander, A, Luoto, T, Öhman, J & Eskola, H 2017, 'Spinal cord injury induces widespread chronic changes in cerebral white matter', Human Brain Mapping, vol. 38, no. 7, pp. 3637-3647. https://doi.org/10.1002/hbm.23619

APA

Ilvesmäki, T., Koskinen, E., Brander, A., Luoto, T., Öhman, J., & Eskola, H. (2017). Spinal cord injury induces widespread chronic changes in cerebral white matter. Human Brain Mapping, 38(7), 3637-3647. https://doi.org/10.1002/hbm.23619

Vancouver

Ilvesmäki T, Koskinen E, Brander A, Luoto T, Öhman J, Eskola H. Spinal cord injury induces widespread chronic changes in cerebral white matter. Human Brain Mapping. 2017;38(7):3637-3647. https://doi.org/10.1002/hbm.23619

Author

Ilvesmäki, Tero ; Koskinen, Eerika ; Brander, Antti ; Luoto, Teemu ; Öhman, Juha ; Eskola, Hannu. / Spinal cord injury induces widespread chronic changes in cerebral white matter. In: Human Brain Mapping. 2017 ; Vol. 38, No. 7. pp. 3637-3647.

Bibtex - Download

@article{72e7cf28bd5343f6b8c49af6fe9a59b7,
title = "Spinal cord injury induces widespread chronic changes in cerebral white matter",
abstract = "Traumatic spinal cord injuries (SCIs) lead to axonal damage at the trauma site, as well as disconnections within the central nervous system. While the exact mechanisms of the long-term pathophysiological consequences of SCIs are not fully understood, it is known that neuronal damage and degeneration are not limited to the direct proximity of the trauma. Instead, the effects can be detected even in the cerebrum. We examined SCI-induced chronic brain changes with a case-control design using 32 patients and 70 control subjects. Whole-brain white matter (WM) tracts were assessed with diffusion tensor imaging (DTI). In addition, we analysed associations between DTI metrics and several clinical SCI variables. Whole-brain analyses were executed by tract-based spatial statistics (TBSS), with an additional complementary atlas-based analysis (ABA). We observed widespread, statistically significant (P≤0.01) changes similar to neural degeneration in SCI patients, both in the corticospinal tract (CST) and beyond. In addition, associations between DTI metrics and time since injury were found with TBSS and ABA, implying possible long-term post-injury neural regeneration. Using the ABA approach, we observed a correlation between SCI severity and DTI metrics, indicating a decrease in WM integrity along with patient sensory or motor scores. Our results suggest a widespread neurodegenerative effect of SCI within the cerebrum that is not limited to the motor pathways. Furthermore, DTI-measured WM integrity of chronic SCI patients seemed to improve as time elapsed since injury.",
keywords = "Cerebrum, Diffusion tensor imaging, Humans, Spinal cord injuries, White matter",
author = "Tero Ilvesm{\"a}ki and Eerika Koskinen and Antti Brander and Teemu Luoto and Juha {\"O}hman and Hannu Eskola",
year = "2017",
doi = "10.1002/hbm.23619",
language = "English",
volume = "38",
pages = "3637--3647",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley",
number = "7",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Spinal cord injury induces widespread chronic changes in cerebral white matter

AU - Ilvesmäki, Tero

AU - Koskinen, Eerika

AU - Brander, Antti

AU - Luoto, Teemu

AU - Öhman, Juha

AU - Eskola, Hannu

PY - 2017

Y1 - 2017

N2 - Traumatic spinal cord injuries (SCIs) lead to axonal damage at the trauma site, as well as disconnections within the central nervous system. While the exact mechanisms of the long-term pathophysiological consequences of SCIs are not fully understood, it is known that neuronal damage and degeneration are not limited to the direct proximity of the trauma. Instead, the effects can be detected even in the cerebrum. We examined SCI-induced chronic brain changes with a case-control design using 32 patients and 70 control subjects. Whole-brain white matter (WM) tracts were assessed with diffusion tensor imaging (DTI). In addition, we analysed associations between DTI metrics and several clinical SCI variables. Whole-brain analyses were executed by tract-based spatial statistics (TBSS), with an additional complementary atlas-based analysis (ABA). We observed widespread, statistically significant (P≤0.01) changes similar to neural degeneration in SCI patients, both in the corticospinal tract (CST) and beyond. In addition, associations between DTI metrics and time since injury were found with TBSS and ABA, implying possible long-term post-injury neural regeneration. Using the ABA approach, we observed a correlation between SCI severity and DTI metrics, indicating a decrease in WM integrity along with patient sensory or motor scores. Our results suggest a widespread neurodegenerative effect of SCI within the cerebrum that is not limited to the motor pathways. Furthermore, DTI-measured WM integrity of chronic SCI patients seemed to improve as time elapsed since injury.

AB - Traumatic spinal cord injuries (SCIs) lead to axonal damage at the trauma site, as well as disconnections within the central nervous system. While the exact mechanisms of the long-term pathophysiological consequences of SCIs are not fully understood, it is known that neuronal damage and degeneration are not limited to the direct proximity of the trauma. Instead, the effects can be detected even in the cerebrum. We examined SCI-induced chronic brain changes with a case-control design using 32 patients and 70 control subjects. Whole-brain white matter (WM) tracts were assessed with diffusion tensor imaging (DTI). In addition, we analysed associations between DTI metrics and several clinical SCI variables. Whole-brain analyses were executed by tract-based spatial statistics (TBSS), with an additional complementary atlas-based analysis (ABA). We observed widespread, statistically significant (P≤0.01) changes similar to neural degeneration in SCI patients, both in the corticospinal tract (CST) and beyond. In addition, associations between DTI metrics and time since injury were found with TBSS and ABA, implying possible long-term post-injury neural regeneration. Using the ABA approach, we observed a correlation between SCI severity and DTI metrics, indicating a decrease in WM integrity along with patient sensory or motor scores. Our results suggest a widespread neurodegenerative effect of SCI within the cerebrum that is not limited to the motor pathways. Furthermore, DTI-measured WM integrity of chronic SCI patients seemed to improve as time elapsed since injury.

KW - Cerebrum

KW - Diffusion tensor imaging

KW - Humans

KW - Spinal cord injuries

KW - White matter

U2 - 10.1002/hbm.23619

DO - 10.1002/hbm.23619

M3 - Article

VL - 38

SP - 3637

EP - 3647

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 7

ER -