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Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose

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Details

Original languageEnglish
Pages (from-to)76-83
Number of pages8
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume64
Issue number2
DOIs
Publication statusPublished - 20 Jul 2015
Publication typeA1 Journal article-refereed

Abstract

Hydrophobically modified hydroxyethylcellulose (HM-HEC) of different hydrophobicity has been used to stabilize pluronic gels against dissolution in an aqueous environment. While pluronic by itself dissolves within 1-2 days, the addition of HM-HEC can stabilize part of the gels from dissolving for a period of at least six months. A larger fraction of the gel remains undissolved when utilizing high HM-HEC concentrations and when the degree of hydrophobic modification is increased. The stabilization against fast dissolution makes these systems interesting for drug delivery purposes. The effect of HM-HEC addition on rheological properties of pluronic gels has also been examined. For a low pluronic concentration, the addition of HM-HEC increases the viscosity of the sample, shifts the gel transition to a lower temperature, and reduces the deviscosification of the pluronic gels at high temperatures. When the pluronic concentration is increased, the addition of HM-HEC only affects the sample viscosity at low temperatures.

Publication forum classification

Field of science, Statistics Finland