Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose
Research output: Contribution to journal › Article › Scientific › peer-review
|Number of pages||8|
|Journal||International Journal of Polymeric Materials and Polymeric Biomaterials|
|Publication status||Published - 20 Jul 2015|
|Publication type||A1 Journal article-refereed|
Hydrophobically modified hydroxyethylcellulose (HM-HEC) of different hydrophobicity has been used to stabilize pluronic gels against dissolution in an aqueous environment. While pluronic by itself dissolves within 1-2 days, the addition of HM-HEC can stabilize part of the gels from dissolving for a period of at least six months. A larger fraction of the gel remains undissolved when utilizing high HM-HEC concentrations and when the degree of hydrophobic modification is increased. The stabilization against fast dissolution makes these systems interesting for drug delivery purposes. The effect of HM-HEC addition on rheological properties of pluronic gels has also been examined. For a low pluronic concentration, the addition of HM-HEC increases the viscosity of the sample, shifts the gel transition to a lower temperature, and reduces the deviscosification of the pluronic gels at high temperatures. When the pluronic concentration is increased, the addition of HM-HEC only affects the sample viscosity at low temperatures.