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Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose

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Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose. / Kjoniksen, Anna-Lena; Calejo, Maria Teresa; Zhu, Kaizheng; Nyström, Bo; Sande, Sverre Arne.

In: International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 64, No. 2, 20.07.2015, p. 76-83.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Kjoniksen, A-L, Calejo, MT, Zhu, K, Nyström, B & Sande, SA 2015, 'Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose', International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 64, no. 2, pp. 76-83. https://doi.org/10.1080/00914037.2014.886245

APA

Kjoniksen, A-L., Calejo, M. T., Zhu, K., Nyström, B., & Sande, S. A. (2015). Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose. International Journal of Polymeric Materials and Polymeric Biomaterials, 64(2), 76-83. https://doi.org/10.1080/00914037.2014.886245

Vancouver

Kjoniksen A-L, Calejo MT, Zhu K, Nyström B, Sande SA. Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose. International Journal of Polymeric Materials and Polymeric Biomaterials. 2015 Jul 20;64(2):76-83. https://doi.org/10.1080/00914037.2014.886245

Author

Kjoniksen, Anna-Lena ; Calejo, Maria Teresa ; Zhu, Kaizheng ; Nyström, Bo ; Sande, Sverre Arne. / Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose. In: International Journal of Polymeric Materials and Polymeric Biomaterials. 2015 ; Vol. 64, No. 2. pp. 76-83.

Bibtex - Download

@article{532f7f7483ee4adcb0a53b752839bdd4,
title = "Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose",
abstract = "Hydrophobically modified hydroxyethylcellulose (HM-HEC) of different hydrophobicity has been used to stabilize pluronic gels against dissolution in an aqueous environment. While pluronic by itself dissolves within 1-2 days, the addition of HM-HEC can stabilize part of the gels from dissolving for a period of at least six months. A larger fraction of the gel remains undissolved when utilizing high HM-HEC concentrations and when the degree of hydrophobic modification is increased. The stabilization against fast dissolution makes these systems interesting for drug delivery purposes. The effect of HM-HEC addition on rheological properties of pluronic gels has also been examined. For a low pluronic concentration, the addition of HM-HEC increases the viscosity of the sample, shifts the gel transition to a lower temperature, and reduces the deviscosification of the pluronic gels at high temperatures. When the pluronic concentration is increased, the addition of HM-HEC only affects the sample viscosity at low temperatures.",
author = "Anna-Lena Kjoniksen and Calejo, {Maria Teresa} and Kaizheng Zhu and Bo Nystr{\"o}m and Sande, {Sverre Arne}",
note = "Contribution: organisation=elt,FACT1=1<br/>Portfolio EDEND: 2014-11-11<br/>Publisher name: Taylor & Francis",
year = "2015",
month = "7",
day = "20",
doi = "10.1080/00914037.2014.886245",
language = "English",
volume = "64",
pages = "76--83",
journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",
issn = "1026-7751",
publisher = "Taylor & Francis",
number = "2",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Stabilization of Pluronic Gels by Hydrophobically Modified Hydroxyethylcellulose

AU - Kjoniksen, Anna-Lena

AU - Calejo, Maria Teresa

AU - Zhu, Kaizheng

AU - Nyström, Bo

AU - Sande, Sverre Arne

N1 - Contribution: organisation=elt,FACT1=1<br/>Portfolio EDEND: 2014-11-11<br/>Publisher name: Taylor & Francis

PY - 2015/7/20

Y1 - 2015/7/20

N2 - Hydrophobically modified hydroxyethylcellulose (HM-HEC) of different hydrophobicity has been used to stabilize pluronic gels against dissolution in an aqueous environment. While pluronic by itself dissolves within 1-2 days, the addition of HM-HEC can stabilize part of the gels from dissolving for a period of at least six months. A larger fraction of the gel remains undissolved when utilizing high HM-HEC concentrations and when the degree of hydrophobic modification is increased. The stabilization against fast dissolution makes these systems interesting for drug delivery purposes. The effect of HM-HEC addition on rheological properties of pluronic gels has also been examined. For a low pluronic concentration, the addition of HM-HEC increases the viscosity of the sample, shifts the gel transition to a lower temperature, and reduces the deviscosification of the pluronic gels at high temperatures. When the pluronic concentration is increased, the addition of HM-HEC only affects the sample viscosity at low temperatures.

AB - Hydrophobically modified hydroxyethylcellulose (HM-HEC) of different hydrophobicity has been used to stabilize pluronic gels against dissolution in an aqueous environment. While pluronic by itself dissolves within 1-2 days, the addition of HM-HEC can stabilize part of the gels from dissolving for a period of at least six months. A larger fraction of the gel remains undissolved when utilizing high HM-HEC concentrations and when the degree of hydrophobic modification is increased. The stabilization against fast dissolution makes these systems interesting for drug delivery purposes. The effect of HM-HEC addition on rheological properties of pluronic gels has also been examined. For a low pluronic concentration, the addition of HM-HEC increases the viscosity of the sample, shifts the gel transition to a lower temperature, and reduces the deviscosification of the pluronic gels at high temperatures. When the pluronic concentration is increased, the addition of HM-HEC only affects the sample viscosity at low temperatures.

U2 - 10.1080/00914037.2014.886245

DO - 10.1080/00914037.2014.886245

M3 - Article

VL - 64

SP - 76

EP - 83

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

SN - 1026-7751

IS - 2

ER -