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Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: A prospective comparative study

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Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast : A prospective comparative study. / Peltoniemi, Hilkka H.; Salmi, Asko; Miettinen, Susanna; Mannerström, Bettina; Saariniemi, Kai; Mikkonen, Raija; Kuokkanen, Hannu; Herold, Christian.

In: JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, Vol. 66, No. 11, 11.2013, p. 1494-1503.

Research output: Contribution to journalReview ArticleScientificpeer-review

Harvard

Peltoniemi, HH, Salmi, A, Miettinen, S, Mannerström, B, Saariniemi, K, Mikkonen, R, Kuokkanen, H & Herold, C 2013, 'Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: A prospective comparative study', JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, vol. 66, no. 11, pp. 1494-1503. https://doi.org/10.1016/j.bjps.2013.06.002

APA

Peltoniemi, H. H., Salmi, A., Miettinen, S., Mannerström, B., Saariniemi, K., Mikkonen, R., ... Herold, C. (2013). Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: A prospective comparative study. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 66(11), 1494-1503. https://doi.org/10.1016/j.bjps.2013.06.002

Vancouver

Peltoniemi HH, Salmi A, Miettinen S, Mannerström B, Saariniemi K, Mikkonen R et al. Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: A prospective comparative study. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY. 2013 Nov;66(11):1494-1503. https://doi.org/10.1016/j.bjps.2013.06.002

Author

Peltoniemi, Hilkka H. ; Salmi, Asko ; Miettinen, Susanna ; Mannerström, Bettina ; Saariniemi, Kai ; Mikkonen, Raija ; Kuokkanen, Hannu ; Herold, Christian. / Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast : A prospective comparative study. In: JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY. 2013 ; Vol. 66, No. 11. pp. 1494-1503.

Bibtex - Download

@article{90ab57bcf1944cbdbece374986f22bcf,
title = "Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: A prospective comparative study",
abstract = "Background Stem cell enrichment is generally believed to be of crucial importance for success in lipofilling for cosmetic breast augmentation. No comparative clinical studies have been reported to support this. Methods A total of 18 women underwent breast augmentation with water-assisted lipotransfer (WAL). In 10 of the cases, transferred lipoaspirate was enriched with stromal stem cells using the Celution{\circledR} system (Cytori Therapeutics Inc., San Diego, Ca, USA). Magnetic resonance imaging (MRI)-based volumetric analysis was done preoperatively and 6 months after the procedure. To verify scientifically that stem cells were transplanted, samples of the transplanted tissues were processed in the laboratory to isolate the adipose stem cells (ASCs). Results MRI volumetry revealed a volume survival of the whole (watery) graft of mean 54{\%} (SD 7) in the WAL only and of 50{\%} (SD 10) in the WAL with stem cell-enrichment patients. As centrifugation of the WAL grafts demonstrated an average adipose tissue of 68{\%}, the average volume survival of adipose tissue itself was 79{\%} (SD 13) in the WAL only and 74{\%} (SD 14) in the WAL with stem cell-enrichment patients. This difference (4.5{\%}) was not statistically significant (independent samples t test, p = 0.330, 95{\%} confidence interval of difference, 4.8, 13.9{\%}). Conclusions Breast augmentation by lipofilling using WAL alone is faster, cheaper, has a lower risk of contamination and offers at least an equal take rate. We do not see any advantage in stem cell enrichment by the Celution{\circledR} system in cosmetic fat transplantation to the breast.",
keywords = "BEAULI, Fat transplantation, Lipofilling, Stem cell, Volumetry, WAL",
author = "Peltoniemi, {Hilkka H.} and Asko Salmi and Susanna Miettinen and Bettina Mannerstr{\"o}m and Kai Saariniemi and Raija Mikkonen and Hannu Kuokkanen and Christian Herold",
year = "2013",
month = "11",
doi = "10.1016/j.bjps.2013.06.002",
language = "English",
volume = "66",
pages = "1494--1503",
journal = "JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY",
issn = "1748-6815",
publisher = "Elsevier",
number = "11",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast

T2 - A prospective comparative study

AU - Peltoniemi, Hilkka H.

AU - Salmi, Asko

AU - Miettinen, Susanna

AU - Mannerström, Bettina

AU - Saariniemi, Kai

AU - Mikkonen, Raija

AU - Kuokkanen, Hannu

AU - Herold, Christian

PY - 2013/11

Y1 - 2013/11

N2 - Background Stem cell enrichment is generally believed to be of crucial importance for success in lipofilling for cosmetic breast augmentation. No comparative clinical studies have been reported to support this. Methods A total of 18 women underwent breast augmentation with water-assisted lipotransfer (WAL). In 10 of the cases, transferred lipoaspirate was enriched with stromal stem cells using the Celution® system (Cytori Therapeutics Inc., San Diego, Ca, USA). Magnetic resonance imaging (MRI)-based volumetric analysis was done preoperatively and 6 months after the procedure. To verify scientifically that stem cells were transplanted, samples of the transplanted tissues were processed in the laboratory to isolate the adipose stem cells (ASCs). Results MRI volumetry revealed a volume survival of the whole (watery) graft of mean 54% (SD 7) in the WAL only and of 50% (SD 10) in the WAL with stem cell-enrichment patients. As centrifugation of the WAL grafts demonstrated an average adipose tissue of 68%, the average volume survival of adipose tissue itself was 79% (SD 13) in the WAL only and 74% (SD 14) in the WAL with stem cell-enrichment patients. This difference (4.5%) was not statistically significant (independent samples t test, p = 0.330, 95% confidence interval of difference, 4.8, 13.9%). Conclusions Breast augmentation by lipofilling using WAL alone is faster, cheaper, has a lower risk of contamination and offers at least an equal take rate. We do not see any advantage in stem cell enrichment by the Celution® system in cosmetic fat transplantation to the breast.

AB - Background Stem cell enrichment is generally believed to be of crucial importance for success in lipofilling for cosmetic breast augmentation. No comparative clinical studies have been reported to support this. Methods A total of 18 women underwent breast augmentation with water-assisted lipotransfer (WAL). In 10 of the cases, transferred lipoaspirate was enriched with stromal stem cells using the Celution® system (Cytori Therapeutics Inc., San Diego, Ca, USA). Magnetic resonance imaging (MRI)-based volumetric analysis was done preoperatively and 6 months after the procedure. To verify scientifically that stem cells were transplanted, samples of the transplanted tissues were processed in the laboratory to isolate the adipose stem cells (ASCs). Results MRI volumetry revealed a volume survival of the whole (watery) graft of mean 54% (SD 7) in the WAL only and of 50% (SD 10) in the WAL with stem cell-enrichment patients. As centrifugation of the WAL grafts demonstrated an average adipose tissue of 68%, the average volume survival of adipose tissue itself was 79% (SD 13) in the WAL only and 74% (SD 14) in the WAL with stem cell-enrichment patients. This difference (4.5%) was not statistically significant (independent samples t test, p = 0.330, 95% confidence interval of difference, 4.8, 13.9%). Conclusions Breast augmentation by lipofilling using WAL alone is faster, cheaper, has a lower risk of contamination and offers at least an equal take rate. We do not see any advantage in stem cell enrichment by the Celution® system in cosmetic fat transplantation to the breast.

KW - BEAULI

KW - Fat transplantation

KW - Lipofilling

KW - Stem cell

KW - Volumetry

KW - WAL

UR - http://www.scopus.com/inward/record.url?scp=84885418334&partnerID=8YFLogxK

U2 - 10.1016/j.bjps.2013.06.002

DO - 10.1016/j.bjps.2013.06.002

M3 - Review Article

VL - 66

SP - 1494

EP - 1503

JO - JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY

JF - JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY

SN - 1748-6815

IS - 11

ER -