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The concurrent use of aromatase inhibitors and radiotherapy induces echocardiographic changes in patients with breast cancer

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)1559-1566
Number of pages8
JournalAnticancer Research
Volume35
Issue number3
Publication statusPublished - 1 Mar 2015
Publication typeA1 Journal article-refereed

Abstract

Aim: Adjuvant radiotherapy (RT) for left-sided breast cancer has a negative impact on cardiac health. The concurrent use of aromatase inhibitors (AIs) during RT was found to increase the anticancer efficacy of radiation in preclinical models. We evaluated whether the acute effects of RT on cardiac functions are augmented by the concurrent use of AIs. Patients and Methods: Sixty patients with early-stage left-sided breast cancer underwent a 2D echocardiography, electrocardiogram and cardiac biomarker measurements before and after adjuvant breast RT. Data were analyzed in two groups according to AI use. Results: We observed a significant (p

ASJC Scopus subject areas

Keywords

  • Aromatase inhinitors, Breast cancer, Cardiotoxicity, Radiotherapy