The effect of inferior turbinate surgery on ciliated epithelium: a randomized, blinded study
Research output: Contribution to journal › Article › Scientific › peer-review
|Number of pages||7|
|Early online date||2018|
|Publication status||Published - Jan 2019|
|Publication type||A1 Journal article-refereed|
Study Design: Prospective randomized study.
Methods: A total of 66 consecutively randomized adult patients with enlarged inferior turbinates underwent either a radiofrequency ablation, diode laser, or microdebrider-assisted inferior turbinoplasty procedure. Assessments were conducted prior to surgery and 3 months subsequent to the surgery. The effect on ciliated epithelium was evaluated using a score based on the blinded grading of the preoperative and postoperative scanning electron microscopy images of mucosal samples. The effect on mucociliary function, in turn, was evaluated using saccharin transit time measurement.
Results: The score of the number of cilia increased statistically signiﬁcantly in the radiofrequency ablation (P = .03) and microdebrider-assisted inferior turbinoplasty (P = .04) groups, but not in the diode laser group. The score of the squamous metaplasia increased statistically signiﬁcantly in the diode laser group (P = .002), but not in the other two groups. There were no signiﬁcant changes found between the preoperative and postoperative saccharin transit time values in any of the treatment groups.
Conclusions: Radiofrequency ablation and microdebrider-assisted inferior turbinoplasty are more mucosal preserving techniques than the diode laser, which was found to increase the amount of squamous metaplasia at the 3-month follow-up.
The number of cilia seemed to even increase after radiofrequency ablation and microdebrider-assisted inferior turbinoplasty
procedures, but not after diode laser. Nevertheless, the mucociliary transport was equally preserved in all three groups.
Key Words: Inferior turbinate, radiofrequency ablation, diode laser, microdebrider-assisted inferior turbinoplasty, cilia,
mucociliary function, scanning electron microscopy.
Level of Evidence: 1b