Tampere University of Technology

TUTCRIS Research Portal

The effect of lipid oxidation on the water permeability of phospholipids bilayers

Research output: Contribution to journalArticleScientificpeer-review

Standard

The effect of lipid oxidation on the water permeability of phospholipids bilayers. / Lis, Mateusz; Wizert, Alicja; Przybylo, Magda; Langner, Marek; Swiatek, Jerzy; Jungwirth, Pavel; Cwiklik, Lukasz.

In: Physical Chemistry Chemical Physics, Vol. 13, No. 39, 21.10.2011, p. 17555-17563.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Lis, M, Wizert, A, Przybylo, M, Langner, M, Swiatek, J, Jungwirth, P & Cwiklik, L 2011, 'The effect of lipid oxidation on the water permeability of phospholipids bilayers', Physical Chemistry Chemical Physics, vol. 13, no. 39, pp. 17555-17563. https://doi.org/10.1039/c1cp21009b

APA

Lis, M., Wizert, A., Przybylo, M., Langner, M., Swiatek, J., Jungwirth, P., & Cwiklik, L. (2011). The effect of lipid oxidation on the water permeability of phospholipids bilayers. Physical Chemistry Chemical Physics, 13(39), 17555-17563. https://doi.org/10.1039/c1cp21009b

Vancouver

Lis M, Wizert A, Przybylo M, Langner M, Swiatek J, Jungwirth P et al. The effect of lipid oxidation on the water permeability of phospholipids bilayers. Physical Chemistry Chemical Physics. 2011 Oct 21;13(39):17555-17563. https://doi.org/10.1039/c1cp21009b

Author

Lis, Mateusz ; Wizert, Alicja ; Przybylo, Magda ; Langner, Marek ; Swiatek, Jerzy ; Jungwirth, Pavel ; Cwiklik, Lukasz. / The effect of lipid oxidation on the water permeability of phospholipids bilayers. In: Physical Chemistry Chemical Physics. 2011 ; Vol. 13, No. 39. pp. 17555-17563.

Bibtex - Download

@article{ac82fbc71b68413586f121c972699dbd,
title = "The effect of lipid oxidation on the water permeability of phospholipids bilayers",
abstract = "The effect of lipid oxidation on water permeability of phosphatidylcholine membranes was investigated by means of both scattering stopped flow experiments and atomistic molecular dynamics simulations. Formation of water pores followed by a significant enhancement of water permeability was observed. The molecules of oxidized phospholipids facilitate pore formation and subsequently stabilize water in the membrane interior. A wide range of oxidation ratios, from 15 to 100 mol{\%}, was considered. The degree of oxidation was found to strongly influence the time needed for the opening of a pore. In simulations, the oxidation ratio of 75 mol{\%} was found to be a threshold for spontaneous pore formation in the tens of nanosecond timescale, whereas 15 mol{\%} of oxidation led to significant water permeation in the timescale of seconds. Once a pore was formed, the water permeability was found to be virtually independent of the oxidation ratio. This journal is",
author = "Mateusz Lis and Alicja Wizert and Magda Przybylo and Marek Langner and Jerzy Swiatek and Pavel Jungwirth and Lukasz Cwiklik",
year = "2011",
month = "10",
day = "21",
doi = "10.1039/c1cp21009b",
language = "English",
volume = "13",
pages = "17555--17563",
journal = "Physical Chemistry Chemical Physics",
issn = "1463-9076",
publisher = "Royal Society of Chemistry",
number = "39",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The effect of lipid oxidation on the water permeability of phospholipids bilayers

AU - Lis, Mateusz

AU - Wizert, Alicja

AU - Przybylo, Magda

AU - Langner, Marek

AU - Swiatek, Jerzy

AU - Jungwirth, Pavel

AU - Cwiklik, Lukasz

PY - 2011/10/21

Y1 - 2011/10/21

N2 - The effect of lipid oxidation on water permeability of phosphatidylcholine membranes was investigated by means of both scattering stopped flow experiments and atomistic molecular dynamics simulations. Formation of water pores followed by a significant enhancement of water permeability was observed. The molecules of oxidized phospholipids facilitate pore formation and subsequently stabilize water in the membrane interior. A wide range of oxidation ratios, from 15 to 100 mol%, was considered. The degree of oxidation was found to strongly influence the time needed for the opening of a pore. In simulations, the oxidation ratio of 75 mol% was found to be a threshold for spontaneous pore formation in the tens of nanosecond timescale, whereas 15 mol% of oxidation led to significant water permeation in the timescale of seconds. Once a pore was formed, the water permeability was found to be virtually independent of the oxidation ratio. This journal is

AB - The effect of lipid oxidation on water permeability of phosphatidylcholine membranes was investigated by means of both scattering stopped flow experiments and atomistic molecular dynamics simulations. Formation of water pores followed by a significant enhancement of water permeability was observed. The molecules of oxidized phospholipids facilitate pore formation and subsequently stabilize water in the membrane interior. A wide range of oxidation ratios, from 15 to 100 mol%, was considered. The degree of oxidation was found to strongly influence the time needed for the opening of a pore. In simulations, the oxidation ratio of 75 mol% was found to be a threshold for spontaneous pore formation in the tens of nanosecond timescale, whereas 15 mol% of oxidation led to significant water permeation in the timescale of seconds. Once a pore was formed, the water permeability was found to be virtually independent of the oxidation ratio. This journal is

UR - http://www.scopus.com/inward/record.url?scp=80053535630&partnerID=8YFLogxK

U2 - 10.1039/c1cp21009b

DO - 10.1039/c1cp21009b

M3 - Article

VL - 13

SP - 17555

EP - 17563

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

SN - 1463-9076

IS - 39

ER -