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The Suzuki, the Heck, and the Stille reaction - Three versatile methods, for the introduction of new C-C bonds on solid support

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Details

Original languageEnglish
Pages (from-to)957-962
Number of pages6
JournalCanadian Journal of Chemistry - Revue Canadienne de Chimie
Volume78
Issue number7
DOIs
Publication statusPublished - 2000
Externally publishedYes
Publication typeA1 Journal article-refereed

Abstract

Metal-catalyzed coupling reactions are very efficient and reliable methods for the introduction of new carbon-carbon bonds onto molecules attached to a solid support. This review summarizes recent advances in utilizing the three most used methods, the Suzuki reaction, the Heck reaction, and the Stille reaction, in the field of solid phase organic synthesis resulting in small organic molecule libraries.

ASJC Scopus subject areas

Keywords

  • Carbon-carbon bonds, Combinatorial chemistry, Drug discovery, Metal-catalyzed coupling reactions, Solid phase synthesis