Tampere University of Technology

TUTCRIS Research Portal

Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

Research output: Contribution to journalArticleScientificpeer-review


Original languageEnglish
Pages (from-to)12507-12510
Number of pages4
JournalChemical Communications
Publication statusPublished - 15 Oct 2018
Publication typeA1 Journal article-refereed


We describe the fast reaction kinetics between 1,2-aminothiols and
aldehydes. Under physiological conditions such a click-type reaction
afforded a thiazolidine product that remains stable and did not
require any catalyst. This type of bioorthogonal reaction offers
enormous potential for the coupling of biomolecules in an efficient
and biocompatible manner

Publication forum classification

Field of science, Statistics Finland