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Tidal breathing flow profiles during sleep in wheezing children measured by impedance pneumography

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Article number103312
JournalRespiratory Physiology and Neurobiology
Volume271
Early online date1 Oct 2019
DOIs
Publication statusE-pub ahead of print - 1 Oct 2019
Publication typeA1 Journal article-refereed

Abstract

For the first time, impedance pneumography (IP) enables a continuous analysis of the tidal breathing flow volume (TBFV), overnight. We studied how corticosteroid inhalation treatments, sleep stage, and time from sleep onset modify the nocturnal TBFV profiles of children. Seventy children, 1–5 years old and with recurrent wheezing, underwent three, full-night TBFVs recordings at home, using IP. The first recorded one week before ending a 3-months inhaled corticosteroids treatment, and remaining two, 2 and 4 weeks after treatment. TBFV profiles were grouped by hour from sleep onset and estimated sleep stage. Compared with on-medication, the off-medication profiles showed lower volume at exhalation peak flow, earlier interruption of expiration, and less convex middle expiration. The differences in the first two features were significant during non-rapid eye movement (NREM), and the differences in the third were more prominent during REM after 4 h of sleep. These combinations of TBFV features, sleep phase, and sleep time potentially indicate airflow limitation in young children.

Keywords

  • Impedance pneumography, Lung function, Tidal breathing, Wheezing children

Publication forum classification

Field of science, Statistics Finland