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Towards in vivo biosensors for low-cost protein sensing

Research output: Contribution to journalArticleScientificpeer-review


Original languageEnglish
Pages (from-to)465-467
Number of pages3
JournalElectronics Letters
Issue number7
Publication statusPublished - 28 Mar 2013
Publication typeA1 Journal article-refereed


In vivo biosensing requires stable transistor operation in high-salt concentration bodily fluids while exhibiting impermeability to mobile alkali ions that would otherwise render the metal-oxide-semiconductor (MOS) threshold voltage to drift. Metal oxide semiconductor capacitor structures using Al 2O3 as the gate dielectric were soaked in a sterile physiological buffer solution (PBS) up to 24 hours and for thicknesses from 100 to 10 nm. The triangular voltage sweep technique characterised alkali ion penetration, and measured no detectable alkali ions for the Al2O 3 capacitors. By contrast, the dose of alkali ions in silicon dioxide MOS capacitors steadily increased with increasing soak times in the PBS solution.

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