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Two cations, two mechanisms: Interactions of sodium and calcium with zwitterionic lipid membranes

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Two cations, two mechanisms : Interactions of sodium and calcium with zwitterionic lipid membranes. / Javanainen, Matti; Melcrová, Adéla; Magarkar, Aniket; Jurkiewicz, Piotr; Hof, Martin; Jungwirth, Pavel; Martinez-Seara, Hector.

In: Chemical Communications, Vol. 53, No. 39, 2017, p. 5380-5383.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Javanainen, M, Melcrová, A, Magarkar, A, Jurkiewicz, P, Hof, M, Jungwirth, P & Martinez-Seara, H 2017, 'Two cations, two mechanisms: Interactions of sodium and calcium with zwitterionic lipid membranes', Chemical Communications, vol. 53, no. 39, pp. 5380-5383. https://doi.org/10.1039/c7cc02208e

APA

Javanainen, M., Melcrová, A., Magarkar, A., Jurkiewicz, P., Hof, M., Jungwirth, P., & Martinez-Seara, H. (2017). Two cations, two mechanisms: Interactions of sodium and calcium with zwitterionic lipid membranes. Chemical Communications, 53(39), 5380-5383. https://doi.org/10.1039/c7cc02208e

Vancouver

Javanainen M, Melcrová A, Magarkar A, Jurkiewicz P, Hof M, Jungwirth P et al. Two cations, two mechanisms: Interactions of sodium and calcium with zwitterionic lipid membranes. Chemical Communications. 2017;53(39):5380-5383. https://doi.org/10.1039/c7cc02208e

Author

Javanainen, Matti ; Melcrová, Adéla ; Magarkar, Aniket ; Jurkiewicz, Piotr ; Hof, Martin ; Jungwirth, Pavel ; Martinez-Seara, Hector. / Two cations, two mechanisms : Interactions of sodium and calcium with zwitterionic lipid membranes. In: Chemical Communications. 2017 ; Vol. 53, No. 39. pp. 5380-5383.

Bibtex - Download

@article{b9ea51c4baa6425d9184416cc5459e75,
title = "Two cations, two mechanisms: Interactions of sodium and calcium with zwitterionic lipid membranes",
abstract = "Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion. It is, however, unclear whether cells can regulate ion adsorption and the related functions via locally adjusting their membrane composition. We employed fluorescence techniques and computer simulations to determine how the presence of cholesterol - a key molecule inducing membrane heterogeneity - affects the adsorption of sodium and calcium onto zwitterionic phosphatidylcholine bilayers. We found that the transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane. Cholesterol thus does not affect sodium adsorption and only plays an indirect role in modulating the adsorption of calcium by increasing the total surface area of the membrane. These observations also indicate how lateral lipid heterogeneity can regulate various ion-induced processes including adsorption of peripheral proteins, nanoparticles, and other molecules onto membranes.",
author = "Matti Javanainen and Ad{\'e}la Melcrov{\'a} and Aniket Magarkar and Piotr Jurkiewicz and Martin Hof and Pavel Jungwirth and Hector Martinez-Seara",
year = "2017",
doi = "10.1039/c7cc02208e",
language = "English",
volume = "53",
pages = "5380--5383",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "ROYAL SOC CHEMISTRY",
number = "39",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Two cations, two mechanisms

T2 - Interactions of sodium and calcium with zwitterionic lipid membranes

AU - Javanainen, Matti

AU - Melcrová, Adéla

AU - Magarkar, Aniket

AU - Jurkiewicz, Piotr

AU - Hof, Martin

AU - Jungwirth, Pavel

AU - Martinez-Seara, Hector

PY - 2017

Y1 - 2017

N2 - Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion. It is, however, unclear whether cells can regulate ion adsorption and the related functions via locally adjusting their membrane composition. We employed fluorescence techniques and computer simulations to determine how the presence of cholesterol - a key molecule inducing membrane heterogeneity - affects the adsorption of sodium and calcium onto zwitterionic phosphatidylcholine bilayers. We found that the transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane. Cholesterol thus does not affect sodium adsorption and only plays an indirect role in modulating the adsorption of calcium by increasing the total surface area of the membrane. These observations also indicate how lateral lipid heterogeneity can regulate various ion-induced processes including adsorption of peripheral proteins, nanoparticles, and other molecules onto membranes.

AB - Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion. It is, however, unclear whether cells can regulate ion adsorption and the related functions via locally adjusting their membrane composition. We employed fluorescence techniques and computer simulations to determine how the presence of cholesterol - a key molecule inducing membrane heterogeneity - affects the adsorption of sodium and calcium onto zwitterionic phosphatidylcholine bilayers. We found that the transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane. Cholesterol thus does not affect sodium adsorption and only plays an indirect role in modulating the adsorption of calcium by increasing the total surface area of the membrane. These observations also indicate how lateral lipid heterogeneity can regulate various ion-induced processes including adsorption of peripheral proteins, nanoparticles, and other molecules onto membranes.

U2 - 10.1039/c7cc02208e

DO - 10.1039/c7cc02208e

M3 - Article

VL - 53

SP - 5380

EP - 5383

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 39

ER -