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Understanding the Role of Lipids in Signaling Through Atomistic and Multiscale Simulations of Cell Membranes

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Understanding the Role of Lipids in Signaling Through Atomistic and Multiscale Simulations of Cell Membranes. / Manna, Moutusi; Nieminen, Tuomo; Vattulainen, Ilpo.

In: ANNUAL REVIEW OF BIOPHYSICS, Vol. 48, 06.05.2019, p. 421-439.

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Manna, Moutusi ; Nieminen, Tuomo ; Vattulainen, Ilpo. / Understanding the Role of Lipids in Signaling Through Atomistic and Multiscale Simulations of Cell Membranes. In: ANNUAL REVIEW OF BIOPHYSICS. 2019 ; Vol. 48. pp. 421-439.

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@article{a274510191d049ca88de0856e82a9a6c,
title = "Understanding the Role of Lipids in Signaling Through Atomistic and Multiscale Simulations of Cell Membranes",
abstract = "Cell signaling controls essentially all cellular processes. While it is often assumed that proteins are the key architects coordinating cell signaling, recent studies have shown more and more clearly that lipids are also involved in signaling processes in a number of ways. Lipids do, for instance, act as messengers, modulate membrane receptor conformation and dynamics, and control membrane receptor partitioning. Further, through structural modifications such as oxidation, the functions of lipids as part of signaling processes can be modified. In this context, in this article we discuss the understanding recently revealed by atomistic and coarse-grained computer simulations of nanoscale processes and underlying physicochemical principles related to lipidsrsquo functions in cellular signaling.",
keywords = "computer simulations, lipids, molecular dynamics, multiscale simulations, signaling",
author = "Moutusi Manna and Tuomo Nieminen and Ilpo Vattulainen",
note = "EXT={"}Manna, Moutusi{"}",
year = "2019",
month = "5",
day = "6",
doi = "10.1146/annurev-biophys-052118-115553",
language = "English",
volume = "48",
pages = "421--439",
journal = "ANNUAL REVIEW OF BIOPHYSICS",
issn = "1936-122X",
publisher = "Annual Reviews",

}

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TY - JOUR

T1 - Understanding the Role of Lipids in Signaling Through Atomistic and Multiscale Simulations of Cell Membranes

AU - Manna, Moutusi

AU - Nieminen, Tuomo

AU - Vattulainen, Ilpo

N1 - EXT="Manna, Moutusi"

PY - 2019/5/6

Y1 - 2019/5/6

N2 - Cell signaling controls essentially all cellular processes. While it is often assumed that proteins are the key architects coordinating cell signaling, recent studies have shown more and more clearly that lipids are also involved in signaling processes in a number of ways. Lipids do, for instance, act as messengers, modulate membrane receptor conformation and dynamics, and control membrane receptor partitioning. Further, through structural modifications such as oxidation, the functions of lipids as part of signaling processes can be modified. In this context, in this article we discuss the understanding recently revealed by atomistic and coarse-grained computer simulations of nanoscale processes and underlying physicochemical principles related to lipidsrsquo functions in cellular signaling.

AB - Cell signaling controls essentially all cellular processes. While it is often assumed that proteins are the key architects coordinating cell signaling, recent studies have shown more and more clearly that lipids are also involved in signaling processes in a number of ways. Lipids do, for instance, act as messengers, modulate membrane receptor conformation and dynamics, and control membrane receptor partitioning. Further, through structural modifications such as oxidation, the functions of lipids as part of signaling processes can be modified. In this context, in this article we discuss the understanding recently revealed by atomistic and coarse-grained computer simulations of nanoscale processes and underlying physicochemical principles related to lipidsrsquo functions in cellular signaling.

KW - computer simulations

KW - lipids

KW - molecular dynamics

KW - multiscale simulations

KW - signaling

U2 - 10.1146/annurev-biophys-052118-115553

DO - 10.1146/annurev-biophys-052118-115553

M3 - Review Article

VL - 48

SP - 421

EP - 439

JO - ANNUAL REVIEW OF BIOPHYSICS

JF - ANNUAL REVIEW OF BIOPHYSICS

SN - 1936-122X

ER -