Tampere University of Technology

TUTCRIS Research Portal

Weekly paclitaxel-An effective treatment for advanced breast cancer

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)2623-2628
Number of pages6
JournalAnticancer Research
Volume33
Issue number6
Publication statusPublished - Jun 2013
Publication typeA1 Journal article-refereed

Abstract

Aim: Weekly paclitaxel is widely used in the treatment of metastatic breast cancer (MBC). Our aim was to test its efficacy and tolerability as a second-line therapy for MBC in daily oncology practice. Patients and Methods: Paclitaxel (90 mg/m2) was given intravenously three times weekly in a 4-week cycle to 91 patients with disease progression after hormonal (42%) or cytostatic therapy (57%). The median age was 54 years; metastatic sites were the lung (39%), liver (52%) and bone (47%). 64% of patients had more than one site of metastasis. Results: Median time- to-progression was 7.5 months (range=6.5-8.5 months) and median overall survival time was 20.1 months (range=13.7-26.5 months). We observed 10 complete (12%) and 37 partial (43%) responses (an overall response rate of 55%). Severe side-effects were rare (grade 3-4 neutropenia 13% and septic episodes in three cases). Conclusion: Weekly paclitaxel was shown to be an effective and well-tolerated treatment for advanced breast cancer.

ASJC Scopus subject areas

Keywords

  • Breast cancer, Docetaxel, Metastasis, Paclitaxel, Survival, Timeto-progression