Tampere University of Technology

TUTCRIS Research Portal

What can we learn about cholesterol’s transmembrane distribution based on cholesterol-induced changes in membrane potential?

Research output: Contribution to journalArticleScientificpeer-review

Standard

What can we learn about cholesterol’s transmembrane distribution based on cholesterol-induced changes in membrane potential? / Falkovich, Stanislav G. ; Martinez-Seara, Hector; Nesterenko, Alexey M.; Vattulainen, Ilpo; Gurtovenko, Andrey A.

In: Journal of Physical Chemistry Letters, Vol. 7, No. 22, 2016, p. 4585-4590 .

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Falkovich, SG, Martinez-Seara, H, Nesterenko, AM, Vattulainen, I & Gurtovenko, AA 2016, 'What can we learn about cholesterol’s transmembrane distribution based on cholesterol-induced changes in membrane potential?', Journal of Physical Chemistry Letters, vol. 7, no. 22, pp. 4585-4590 . https://doi.org/10.1021/acs.jpclett.6b02123

APA

Falkovich, S. G., Martinez-Seara, H., Nesterenko, A. M., Vattulainen, I., & Gurtovenko, A. A. (2016). What can we learn about cholesterol’s transmembrane distribution based on cholesterol-induced changes in membrane potential? Journal of Physical Chemistry Letters, 7(22), 4585-4590 . https://doi.org/10.1021/acs.jpclett.6b02123

Vancouver

Falkovich SG, Martinez-Seara H, Nesterenko AM, Vattulainen I, Gurtovenko AA. What can we learn about cholesterol’s transmembrane distribution based on cholesterol-induced changes in membrane potential? Journal of Physical Chemistry Letters. 2016;7(22):4585-4590 . https://doi.org/10.1021/acs.jpclett.6b02123

Author

Falkovich, Stanislav G. ; Martinez-Seara, Hector ; Nesterenko, Alexey M. ; Vattulainen, Ilpo ; Gurtovenko, Andrey A. / What can we learn about cholesterol’s transmembrane distribution based on cholesterol-induced changes in membrane potential?. In: Journal of Physical Chemistry Letters. 2016 ; Vol. 7, No. 22. pp. 4585-4590 .

Bibtex - Download

@article{bc65537c4adb4a0eb648a307d1e21e1a,
title = "What can we learn about cholesterol’s transmembrane distribution based on cholesterol-induced changes in membrane potential?",
abstract = "Cholesterol is abundant in the plasma membranes of animal cells and is known to regulate a variety of membrane properties. Despite decades of research, the transmembrane distribution of cholesterol is still a matter of debate. Here we consider this outstanding issue through atomistic simulations of asymmetric lipid membranes, whose composition is largely consistent with eukaryotic plasma membranes. We show that the membrane dipole potential changes in a cholesterol-dependent manner. Remarkably, moving cholesterol from the extracellular to the cytosolic leaflet increases the dipole potential on the cytosolic side, and vice versa. Biologically this implies that by altering the dipole potential, cholesterol can provide a driving force for cholesterol molecules to favor the cytosolic leaflet, in order to compensate for the intramembrane field that arises from the resting potential.",
author = "Falkovich, {Stanislav G.} and Hector Martinez-Seara and Nesterenko, {Alexey M.} and Ilpo Vattulainen and Gurtovenko, {Andrey A.}",
year = "2016",
doi = "10.1021/acs.jpclett.6b02123",
language = "English",
volume = "7",
pages = "4585--4590",
journal = "Journal of Physical Chemistry Letters",
issn = "1948-7185",
publisher = "American Chemical Society",
number = "22",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - What can we learn about cholesterol’s transmembrane distribution based on cholesterol-induced changes in membrane potential?

AU - Falkovich, Stanislav G.

AU - Martinez-Seara, Hector

AU - Nesterenko, Alexey M.

AU - Vattulainen, Ilpo

AU - Gurtovenko, Andrey A.

PY - 2016

Y1 - 2016

N2 - Cholesterol is abundant in the plasma membranes of animal cells and is known to regulate a variety of membrane properties. Despite decades of research, the transmembrane distribution of cholesterol is still a matter of debate. Here we consider this outstanding issue through atomistic simulations of asymmetric lipid membranes, whose composition is largely consistent with eukaryotic plasma membranes. We show that the membrane dipole potential changes in a cholesterol-dependent manner. Remarkably, moving cholesterol from the extracellular to the cytosolic leaflet increases the dipole potential on the cytosolic side, and vice versa. Biologically this implies that by altering the dipole potential, cholesterol can provide a driving force for cholesterol molecules to favor the cytosolic leaflet, in order to compensate for the intramembrane field that arises from the resting potential.

AB - Cholesterol is abundant in the plasma membranes of animal cells and is known to regulate a variety of membrane properties. Despite decades of research, the transmembrane distribution of cholesterol is still a matter of debate. Here we consider this outstanding issue through atomistic simulations of asymmetric lipid membranes, whose composition is largely consistent with eukaryotic plasma membranes. We show that the membrane dipole potential changes in a cholesterol-dependent manner. Remarkably, moving cholesterol from the extracellular to the cytosolic leaflet increases the dipole potential on the cytosolic side, and vice versa. Biologically this implies that by altering the dipole potential, cholesterol can provide a driving force for cholesterol molecules to favor the cytosolic leaflet, in order to compensate for the intramembrane field that arises from the resting potential.

U2 - 10.1021/acs.jpclett.6b02123

DO - 10.1021/acs.jpclett.6b02123

M3 - Article

VL - 7

SP - 4585

EP - 4590

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

SN - 1948-7185

IS - 22

ER -