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Wireless Optogenetic Neural Dust for Deep Brain Stimulation

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Wireless Optogenetic Neural Dust for Deep Brain Stimulation. / Wirdatmadja, Stefanus A.; Balasubramaniam, Sasitharan; Koucheryavy, Yevgeni; Jornet, Josep Miquel.

2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom). IEEE, 2016.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Harvard

Wirdatmadja, SA, Balasubramaniam, S, Koucheryavy, Y & Jornet, JM 2016, Wireless Optogenetic Neural Dust for Deep Brain Stimulation. in 2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom). IEEE, IEEE INTERNATIONAL CONFERENCE ON E-HEALTH NETWORKING, APPLICATIONS AND SERVICES, 1/01/00. https://doi.org/10.1109/HealthCom.2016.7749532

APA

Wirdatmadja, S. A., Balasubramaniam, S., Koucheryavy, Y., & Jornet, J. M. (2016). Wireless Optogenetic Neural Dust for Deep Brain Stimulation. In 2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom) IEEE. https://doi.org/10.1109/HealthCom.2016.7749532

Vancouver

Wirdatmadja SA, Balasubramaniam S, Koucheryavy Y, Jornet JM. Wireless Optogenetic Neural Dust for Deep Brain Stimulation. In 2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom). IEEE. 2016 https://doi.org/10.1109/HealthCom.2016.7749532

Author

Wirdatmadja, Stefanus A. ; Balasubramaniam, Sasitharan ; Koucheryavy, Yevgeni ; Jornet, Josep Miquel. / Wireless Optogenetic Neural Dust for Deep Brain Stimulation. 2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom). IEEE, 2016.

Bibtex - Download

@inproceedings{29283df568d44079a7a0f9c8e27e80cd,
title = "Wireless Optogenetic Neural Dust for Deep Brain Stimulation",
abstract = "In recent years, numerous research efforts have been dedicated towards developing efficient implantable devices for Deep Brain Stimulation (DBS). However, there are limitations and challenges with the current technologies. Firstly, the stimulation of neurons currently is only possible through implantable electrodes which target a population of neurons. This results in challenges in the event that stimulation at the single neuron level is required. Secondly, a major hurdle still lies in developing miniature devices that can last for a lifetime in the patient's brain. Recently, the concept of neural dust has been introduced as a way to achieve single neuron monitoring and potentially actuation. In parallel to this, the field of optogenetics has emerged where the aim is to stimulate neurons using light, usually by means of optical fibers inserted through the skull. Obviously, this introduces many challenges in terms of user friendliness and biocompatibility. We address this shortcoming by proposing the wireless optogenetic neural dust (wi-opt neural dust). The wiopt neural dust is equipped with a miniature LED that is able to stimulate the genetically engineered neurons, and at the same time harvest energy from ultrasonic vibrations. The simulation results presented in the paper investigates the behaviour of the light propagation in the brain tissue, as well as the performance of designed circuitry for the energy harvesting process. The results demonstrates the feasibility of utilizing wi-opt neural dust for long term implantation in the brain, and a new direction towards precise stimulation of neurons in the cortex.",
author = "Wirdatmadja, {Stefanus A.} and Sasitharan Balasubramaniam and Yevgeni Koucheryavy and Jornet, {Josep Miquel}",
year = "2016",
month = "11",
day = "21",
doi = "10.1109/HealthCom.2016.7749532",
language = "English",
booktitle = "2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom)",
publisher = "IEEE",

}

RIS (suitable for import to EndNote) - Download

TY - GEN

T1 - Wireless Optogenetic Neural Dust for Deep Brain Stimulation

AU - Wirdatmadja, Stefanus A.

AU - Balasubramaniam, Sasitharan

AU - Koucheryavy, Yevgeni

AU - Jornet, Josep Miquel

PY - 2016/11/21

Y1 - 2016/11/21

N2 - In recent years, numerous research efforts have been dedicated towards developing efficient implantable devices for Deep Brain Stimulation (DBS). However, there are limitations and challenges with the current technologies. Firstly, the stimulation of neurons currently is only possible through implantable electrodes which target a population of neurons. This results in challenges in the event that stimulation at the single neuron level is required. Secondly, a major hurdle still lies in developing miniature devices that can last for a lifetime in the patient's brain. Recently, the concept of neural dust has been introduced as a way to achieve single neuron monitoring and potentially actuation. In parallel to this, the field of optogenetics has emerged where the aim is to stimulate neurons using light, usually by means of optical fibers inserted through the skull. Obviously, this introduces many challenges in terms of user friendliness and biocompatibility. We address this shortcoming by proposing the wireless optogenetic neural dust (wi-opt neural dust). The wiopt neural dust is equipped with a miniature LED that is able to stimulate the genetically engineered neurons, and at the same time harvest energy from ultrasonic vibrations. The simulation results presented in the paper investigates the behaviour of the light propagation in the brain tissue, as well as the performance of designed circuitry for the energy harvesting process. The results demonstrates the feasibility of utilizing wi-opt neural dust for long term implantation in the brain, and a new direction towards precise stimulation of neurons in the cortex.

AB - In recent years, numerous research efforts have been dedicated towards developing efficient implantable devices for Deep Brain Stimulation (DBS). However, there are limitations and challenges with the current technologies. Firstly, the stimulation of neurons currently is only possible through implantable electrodes which target a population of neurons. This results in challenges in the event that stimulation at the single neuron level is required. Secondly, a major hurdle still lies in developing miniature devices that can last for a lifetime in the patient's brain. Recently, the concept of neural dust has been introduced as a way to achieve single neuron monitoring and potentially actuation. In parallel to this, the field of optogenetics has emerged where the aim is to stimulate neurons using light, usually by means of optical fibers inserted through the skull. Obviously, this introduces many challenges in terms of user friendliness and biocompatibility. We address this shortcoming by proposing the wireless optogenetic neural dust (wi-opt neural dust). The wiopt neural dust is equipped with a miniature LED that is able to stimulate the genetically engineered neurons, and at the same time harvest energy from ultrasonic vibrations. The simulation results presented in the paper investigates the behaviour of the light propagation in the brain tissue, as well as the performance of designed circuitry for the energy harvesting process. The results demonstrates the feasibility of utilizing wi-opt neural dust for long term implantation in the brain, and a new direction towards precise stimulation of neurons in the cortex.

U2 - 10.1109/HealthCom.2016.7749532

DO - 10.1109/HealthCom.2016.7749532

M3 - Conference contribution

BT - 2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom)

PB - IEEE

ER -