TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

Supplementary data for "Cholesterol modulates glycolipid conformation and receptor activity"

Tietoaineisto

Description

We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.
Saatavilla2017
JulkaisijaTampere University of Technology

ID: 11003594