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A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy

Tutkimustuotosvertaisarvioitu

Standard

A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy. / Hakala, T.; Kholová, I.; Sand, J.; Saaristo, R.; Kellokumpu-Lehtinen, P.

julkaisussa: Journal of Clinical Pathology, Vuosikerta 66, Nro 12, 12.2013, s. 1046-1050.

Tutkimustuotosvertaisarvioitu

Harvard

Hakala, T, Kholová, I, Sand, J, Saaristo, R & Kellokumpu-Lehtinen, P 2013, 'A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy', Journal of Clinical Pathology, Vuosikerta. 66, Nro 12, Sivut 1046-1050. https://doi.org/10.1136/jclinpath-2013-201559

APA

Hakala, T., Kholová, I., Sand, J., Saaristo, R., & Kellokumpu-Lehtinen, P. (2013). A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy. Journal of Clinical Pathology, 66(12), 1046-1050. https://doi.org/10.1136/jclinpath-2013-201559

Vancouver

Hakala T, Kholová I, Sand J, Saaristo R, Kellokumpu-Lehtinen P. A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy. Journal of Clinical Pathology. 2013 joulu;66(12):1046-1050. https://doi.org/10.1136/jclinpath-2013-201559

Author

Hakala, T. ; Kholová, I. ; Sand, J. ; Saaristo, R. ; Kellokumpu-Lehtinen, P. / A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy. Julkaisussa: Journal of Clinical Pathology. 2013 ; Vuosikerta 66, Nro 12. Sivut 1046-1050.

Bibtex - Lataa

@article{a1a8298680924b5c8240d7c4ac0910be,
title = "A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy",
abstract = "Background and aims: The most commonly used diagnostic method for the preoperative diagnosis of thyroid nodules is ultrasound-guided fine-needle aspiration biopsy (FNA), which often yields non-diagnostic or non-definitive results and seldom produces definite malignant diagnoses. To improve upon the malignancy-specific sensitivity, we tested core needle biopsies (CNBs) of thyroid lesions taken from surgical specimens. Material and methods: 52 consecutive patients with malignant or malignant-suspicious thyroid nodules were referred to Tampere University Hospital between May 2010 and December 2011. Preoperative FNAs were categorised as follicular neoplasm (48{\%}), suspicion for malignancy (46{\%}) or malignancy (6{\%}). Intraoperative FNA and CNB samples were acquired from surgical specimens removed during surgery. The results of the needle biopsies were compared with the final pathological diagnosis. Results: CNBs had a high definitive sensitivity for malignancy (61{\%}, CI 41{\%} to 78{\%}) whereas the definitive sensitivity for malignancy of FNAs was significantly lower (22{\%}, CI 10{\%} to 42{\%}). CNB was not bene ficial in the diagnosis of follicular thyroid lesions. When all suspected follicular tumours were excluded, the definitive sensitivity of CNB rose to 70{\%} (CI 48{\%} to 86{\%}). Conclusions: CNB may be beneficial for the diagnosis of papillary thyroid carcinoma and other non-follicular thyroid lesions. CNB may be considered as an additional diagnostic procedure in cases with FNA suspicious for malignancy.",
author = "T. Hakala and I. Kholov{\'a} and J. Sand and R. Saaristo and P. Kellokumpu-Lehtinen",
year = "2013",
month = "12",
doi = "10.1136/jclinpath-2013-201559",
language = "English",
volume = "66",
pages = "1046--1050",
journal = "Journal of Clinical Pathology",
issn = "0021-9746",
publisher = "BMJ Publishing Group",
number = "12",

}

RIS (suitable for import to EndNote) - Lataa

TY - JOUR

T1 - A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy

AU - Hakala, T.

AU - Kholová, I.

AU - Sand, J.

AU - Saaristo, R.

AU - Kellokumpu-Lehtinen, P.

PY - 2013/12

Y1 - 2013/12

N2 - Background and aims: The most commonly used diagnostic method for the preoperative diagnosis of thyroid nodules is ultrasound-guided fine-needle aspiration biopsy (FNA), which often yields non-diagnostic or non-definitive results and seldom produces definite malignant diagnoses. To improve upon the malignancy-specific sensitivity, we tested core needle biopsies (CNBs) of thyroid lesions taken from surgical specimens. Material and methods: 52 consecutive patients with malignant or malignant-suspicious thyroid nodules were referred to Tampere University Hospital between May 2010 and December 2011. Preoperative FNAs were categorised as follicular neoplasm (48%), suspicion for malignancy (46%) or malignancy (6%). Intraoperative FNA and CNB samples were acquired from surgical specimens removed during surgery. The results of the needle biopsies were compared with the final pathological diagnosis. Results: CNBs had a high definitive sensitivity for malignancy (61%, CI 41% to 78%) whereas the definitive sensitivity for malignancy of FNAs was significantly lower (22%, CI 10% to 42%). CNB was not bene ficial in the diagnosis of follicular thyroid lesions. When all suspected follicular tumours were excluded, the definitive sensitivity of CNB rose to 70% (CI 48% to 86%). Conclusions: CNB may be beneficial for the diagnosis of papillary thyroid carcinoma and other non-follicular thyroid lesions. CNB may be considered as an additional diagnostic procedure in cases with FNA suspicious for malignancy.

AB - Background and aims: The most commonly used diagnostic method for the preoperative diagnosis of thyroid nodules is ultrasound-guided fine-needle aspiration biopsy (FNA), which often yields non-diagnostic or non-definitive results and seldom produces definite malignant diagnoses. To improve upon the malignancy-specific sensitivity, we tested core needle biopsies (CNBs) of thyroid lesions taken from surgical specimens. Material and methods: 52 consecutive patients with malignant or malignant-suspicious thyroid nodules were referred to Tampere University Hospital between May 2010 and December 2011. Preoperative FNAs were categorised as follicular neoplasm (48%), suspicion for malignancy (46%) or malignancy (6%). Intraoperative FNA and CNB samples were acquired from surgical specimens removed during surgery. The results of the needle biopsies were compared with the final pathological diagnosis. Results: CNBs had a high definitive sensitivity for malignancy (61%, CI 41% to 78%) whereas the definitive sensitivity for malignancy of FNAs was significantly lower (22%, CI 10% to 42%). CNB was not bene ficial in the diagnosis of follicular thyroid lesions. When all suspected follicular tumours were excluded, the definitive sensitivity of CNB rose to 70% (CI 48% to 86%). Conclusions: CNB may be beneficial for the diagnosis of papillary thyroid carcinoma and other non-follicular thyroid lesions. CNB may be considered as an additional diagnostic procedure in cases with FNA suspicious for malignancy.

UR - http://www.scopus.com/inward/record.url?scp=84892789695&partnerID=8YFLogxK

U2 - 10.1136/jclinpath-2013-201559

DO - 10.1136/jclinpath-2013-201559

M3 - Article

VL - 66

SP - 1046

EP - 1050

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

SN - 0021-9746

IS - 12

ER -