A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
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Yksityiskohdat
| Alkuperäiskieli | Englanti |
|---|---|
| Sivut | 1103-1109 |
| Sivumäärä | 7 |
| Julkaisu | Nature Genetics |
| Vuosikerta | 46 |
| Numero | 10 |
| DOI - pysyväislinkit | |
| Tila | Julkaistu - 26 syyskuuta 2014 |
| OKM-julkaisutyyppi | A1 Alkuperäisartikkeli |
Tiivistelmä
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P <5 × 10 â '8; 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.