TUTCRIS - Tampereen teknillinen yliopisto

TUTCRIS

A model to estimate the outcome of prostate cancer photodynamic therapy with TOOKAD soluble WST11

Tutkimustuotosvertaisarvioitu

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut4771-4783
Sivumäärä13
JulkaisuPhysics in Medicine and Biology
Vuosikerta56
Numero15
DOI - pysyväislinkit
TilaJulkaistu - 7 elokuuta 2011
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tiivistelmä

Interstitial photodynamic therapy is becoming an interesting modality to treat some early stage prostate cancers. A light-sensitive drug is injected to the patient and activated by light using optical fibres inserted inside the prostate. In this work, we were interested in the characterization of the light action model for the WST11 (Tookad Soluble) drug. A retrospective analysis was performed on results from 28 patients enrolled in phase I and II trials with the WST11 drug. A drug dose of 4 mg/kg patient, dose light of 200 J cm-1 and wavelength of 753 nm were used. Correlation between the illuminated volume and the obtained necrosis, measured at day 7 MR images, was clearly established. This result suggests that photodynamic therapy planning is possible based on this model.